Results 221 to 230 of about 260,111 (309)

Effect of enteral nutrition nursing combined with gastrointestinal function monitoring on gastric retention and abdominal distension in neurosurgical patients. [PDF]

Medicine (Baltimore)
Lei H, Wang M, Ke P.
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Pretreatment L3 Skeletal Muscle Index Is Associated with Severe Oral Intake Impairment and a Longer Treatment-to-Discharge Interval in Patients with Head and Neck Squamous Cell Carcinoma Receiving Definitive Chemoradiotherapy. [PDF]

Cancers (Basel)
Fukushima Y, Shimizu T, Kakubari T, Kumasaka S, Ozaki D, Sato Y, Takeuchi T, Motegi M, Chikamatsu K, Tsushima Y.   +9 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Perioperative Management of Antirheumatic Medications in Adults with Rheumatoid Arthritis Undergoing Arthroplasty and Other Orthopedic Procedures: A Systematic Review. [PDF]

Medicina (Kaunas)
Al-Obaidi I, Alabid I, Al-Dhaheri A, Qassim ZAM, Patni MM, El-Tanani M, Rabbani SA, Shuaeeb A, Aloti RA, Alghoul WII.   +9 more
europepmc   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Physical Environment Features and Healthcare Interruptions: A Scoping Review Across Clinical Settings. [PDF]

HERD
Pesarakli H, Sasangohar F, Javid AH, Lu Z.   +3 more
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Unintended Interruption of Caplacizumab Therapy Can Compromise Outcomes in Immune-Mediated Thrombotic Thrombocytopenic Purpura: Lessons from Two Clinical Cases. [PDF]

J Clin Med
Özcan F, Kiziler F, Brinkkoetter P, Kühne L, Knöbl P, Brinkhoff A.   +5 more
europepmc   +1 more source