Results 51 to 60 of about 697,316 (261)

Intersection numbers, polynomial division and relative cohomology

open access: yesJournal of High Energy Physics
We present a simplification of the recursive algorithm for the evaluation of intersection numbers for differential n-forms, by combining the advantages emerging from the choice of delta-forms as generators of relative twisted cohomology groups and the ...
Giacomo Brunello   +5 more
doaj   +1 more source

NEW CONCEPTS AND TEST METHODS OF CURVE PROFILE AREA DENSITY IN SURFACE: ESTIMATION OF AREAL DENSITY ON CURVED SPATIAL SURFACE

open access: yesImage Analysis and Stereology, 2011
The concepts of curve profile, curve intercept, curve intercept density, curve profile area density, intersection density in containing intersection (or intersection density relied on intersection reference), curve profile intersection density in surface
Hong Shen
doaj   +1 more source

Matrix Integrals and Feynman Diagrams in the Kontsevich Model

open access: yes, 2003
We review some relations occurring between the combinatorial intersection theory on the moduli spaces of stable curves and the asymptotic behavior of the 't Hooft-Kontsevich matrix integrals.
Fiorenza, Domenico, Murri, Riccardo
core   +3 more sources

5-Designs with three intersection numbers

open access: yesJournal of Combinatorial Theory, Series A, 1995
It is proved that the Witt 5-(24,8,1) design is the unique 5-\((v, k, \lambda)\) design with exactly three intersection numbers if \(k- 1\) is a prime or \(\lambda\leq 4\) or at least two intersection numbers are less than 5.
Ionin, Yury J, Shrikhande, Mohan S
openaire   +2 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

(Fractional) intersection numbers, tadpoles and anomalies [PDF]

open access: yesJournal of High Energy Physics, 2006
We use the Witten index in the open string sector to determine tadpole charges of orientifold planes and D-branes. As specific examples we consider type I compactifications on Calabi Yau manifolds and noncompact orbifolds. The tadpole constraints suggest that the standard embedding is not a natural choice for the gauge bundle.
openaire   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Stable evaluation of Lefschetz thimble intersection numbers:Towards real-time path integrals

open access: yesPhysics Letters B
We introduce a robust numerical method for determining intersection numbers of Lefschetz thimbles in multivariable settings. Our approach employs the multiple shooting method to solve the upward flow equations from the saddle points to the original ...
Yutaro Shoji, Katarina Trailović
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

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