Results 61 to 70 of about 697,316 (261)

Infinitesimal Liouville currents, cross-ratios and intersection numbers

, 2010
Many classical objects on a surface S can be interpreted as cross-ratio functions on the circle at infinity of the universal covering. This includes closed curves considered up to homotopy, metrics of negative curvature considered up to isotopy and, in ...
Bonahon, Francis, Saric, Dragomir
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Emergence of CY triple intersection numbers in M-theory

Journal of High Energy Physics
To give more credence to the M-theoretic Emergence Proposal it is important to show that also classical kinetic terms in a low energy effective action arise as a quantum effect from integrating out light towers of states.
Ralph Blumenhagen, Aleksandar Gligovic
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Intersection types for unbind and rebind [PDF]

Electronic Proceedings in Theoretical Computer Science, 2011
We define a type system with intersection types for an extension of lambda-calculus with unbind and rebind operators. In this calculus, a term with free variables, representing open code, can be packed into an "unbound" term, and passed around as a value.
Mariangiola Dezani-Ciancaglini, Paola Giannini, Elena Zucca   +2 more
doaj   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Machine learning Calabi-Yau four-folds

Physics Letters B, 2021
Hodge numbers of Calabi-Yau manifolds depend non-trivially on the underlying manifold data and they present an interesting challenge for machine learning.
Yang-Hui He, Andre Lukas
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

t-Designs with few intersection numbers

Discrete Mathematics, 1991
The authors present a method to obtain new \(i\)-designs from \(t\)-designs with few intersection numbers provided some numerical conditions are met. Specifically, let \(B\) be a fixed block of a \(t-(v,k,\lambda)\) design having \(j\) distinct intersection numbers. Repeated blocks are allowed. Let \(x\) be an intersection number.
Pott, Alexander, Shrikhande, Mohan
openaire   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source