Results 101 to 110 of about 132,124 (298)

Decoding Undesirable Inflammatory Responses of Nucleic Acid‐Delivering Lipid Nanoparticles

Advanced Science, EarlyView.
Lipid nanoparticles (LNPs) enable efficient nucleic acid delivery, but their immunogenicity is a double‐edged sword. This review explores LNP‐driven innate and adaptive immunity, covering lipid components, endosomal escape, and nucleic acid sensing.
Ruimin Hu, Yin Dou, Chenwen Li, Yuying Mu, Huiying Ouyang, Wenhao Shen, Jianxiang Zhang   +6 more
wiley   +1 more source

Chemical Metabolomics: Chemical Biology Tools for Advanced Metabolism Investigations

Angewandte Chemie, EarlyView.
The human metabolism has been investigated for several millennia. The metabolome is known for a high complexity due to a large number of different metabolites that are present at different concentrations. Metabolomics has been developed as a field to investigate the entire human metabolome and to elucidate disease development mechanisms.
Alejandro Torregrosa‐Chinillach, Ioanna Tsiara, Wawrzyniec Haberek, Weifeng Lin, Daniel Globisch   +4 more
wiley   +2 more sources

Understanding the production of dual BEC with sympathetic cooling

, 2001
We show, both experimentally and theoretically, that sympathetic cooling of $^{87}$Rb atoms in the $|F=2,m_F=2>$ state by evaporatively cooled atoms in the $|F=1,m_F=-1>$ state can be precisely controlled to produce dual or single condensate in either ...
Aspect, A., Bouyer, P., Boyer, V., Delannoy, G., Josse, V., Murdoch, S. G.   +5 more
core   +3 more sources

Metabolism‐Based Biomarkers for Rapid Phenotypic Antibiotic Susceptibility Testing

Advanced Science, EarlyView.
Metabolic differences emerging after antibiotic exposure provide rapid phenotypic signals of susceptibility and resistance. This review summarizes metabolic biomarkers for rapid phenotypic AST, associated with nutrient uptake, respiratory activity, metabolic reprogramming, and enzymatic function. ABSTRACT The accelerating global crisis of antimicrobial
Sha Yu, Bayinqiaoge, Xi Lu, Xin Wang, Rongfeng Wang, Yi Li, Shi‐Yang Tang, Chengchen Zhang   +7 more
wiley   +1 more source

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis

Angewandte Chemie, EarlyView.
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley   +2 more sources

Strong-coupling expansion for the two-species Bose-Hubbard model

, 2010
To analyze the ground-state phase diagram of Bose-Bose mixtures loaded into $d$-dimensional hypercubic optical lattices, we perform a strong-coupling power-series expansion in the kinetic energy term (plus a scaling analysis) for the two-species Bose ...
Iskin, M.
core   +1 more source

Association of HAMP Expression and CD8+ T‐Cell Infiltration With Atezolizumab–Bevacizumab Response in Hepatocellular Carcinoma

Annals of Gastroenterological Surgery, EarlyView.
In hepatocellular carcinoma treated with atezolizumab–bevacizumab, responders showed RNA‐seq enrichment of immune and chemokine pathways with higher HAMP expression. In resected specimens, immunohistochemistry confirmed increased intratumoral CD8+ T‐cell density and hepcidin (HAMP), supporting HAMP plus CD8 as components of a composite predictor of ...
Shun Nakamura, Yuki Murakami, Yusuke Oshima, Takashi Masuda, Wataru Miyoshino, Hiroomi Takayama, Yoko Kawano, Teijiro Hirashita, Yuichi Endo, Masafumi Inomata   +9 more
wiley   +1 more source

Superfluidity of Interacting Bosonic Mixtures in Optical Lattices

, 2010
We report the observation of many-body interaction effects for a homonuclear bosonic mixture in a three-dimensional optical lattice with variable state dependence along one axis. Near the superfluid-to-Mott insulator transition for one component, we find
Gadway, Bryce, Pertot, Daniel, Reimann, René, Schneble, Dominik   +3 more
core   +1 more source

Interspecies Biofilm Dynamics Among Staphylococci: Inflammatory Contributions to Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Introduction Staphylococcus species are frequently isolated from the sinonasal niche of chronic rhinosinusitis (CRS) patients. While Staphylococcus aureus is often associated with recalcitrant CRS, Staphylococcus epidermidis and Staphylococcus lugdunensis are largely deemed commensal.
Sintayehu Ambachew, Mahnaz Ramezanpour, Clare M. Cooksley, Sholeh Feizi, Muhammed Awad, Kevin Aaron Fenix, Peter‐John Wormald, Alkis J. Psaltis, Sarah Vreugde   +8 more
wiley   +1 more source

Weakly Interacting Bose Mixtures at Finite Temperature

, 2009
Motivated by the recent experiments on Bose-Einstein mixtures with tunable interactions we study repulsive weakly interacting Bose mixtures at finite temperature.
Altin, Ao, Bert Van Schaeybroeck, Bhongale, Esry, Gerbier, Giorgini, Hall, Ho, Holzmann, Huang, Huang, Indekeu, Jezek, Law, McCarron, Papp, Papp, Partridge, Pethick, Pilch, Pitaevskii, Proukakis, Riboli, Ronen, Shi, Stenger, Thalhammer, Timmermans, Tojo, Trippenbach, Van Schaeybroeck, Öhberg   +32 more
core   +1 more source