Results 61 to 70 of about 2,671,907 (218)

Adaptive evolution of the spike gene of SARS coronavirus: changes in positively selected sites in different epidemic groups

BMC Microbiology, 2006
Background It is believed that animal-to-human transmission of severe acute respiratory syndrome (SARS) coronavirus (CoV) is the cause of the SARS outbreak worldwide.
He Shao-Heng, Wei Ji-Fu, Zhang Chi-Yu
doaj   +1 more source

From birds to mammals: spillover of highly pathogenic avian influenza H5N1 virus to dairy cattle led to efficient intra- and interspecies transmission

bioRxiv
Infections with the highly pathogenic avian influenza (HPAI) H5N1 clade 2.3.4.4b virus have resulted in the death of millions of domestic birds and thousands of wild birds in the U.S.
L. Caserta, Elisha A. Frye, Salman L. Butt, Melissa Laverack, M. Nooruzzaman, L. Covaleda, Alexis C. Thompson, Melanie Prarat Koscielny, B. Cronk, Ashley Johnson, Katie Kleinhenz, Erin E. Edwards, Gabriel Gomez, Gavin Hitchener, Mathias Martins, D. Kapczynski, D. L. Suarez, Ellen Ruth Alexander Morris, Terry Hensley, John S. Beeby, Manigandan Lejeune, A. Swinford, François Elvinger, K. Dimitrov, D. Diel   +24 more
semanticscholar   +1 more source

Diversity and Potential Cross-Species Transmission of Rotavirus A in Wild Animals in Yunnan, China

Microorganisms
Rotavirus A (RVA) is the primary enteric pathogen of humans and many other species. However, RVA interspecies transmission remains poorly understood. In this study, we conducted a comprehensive screening and genotyping analysis of RVA in 1706 wild animal
Xiang Le, Yinzhu Tao, Binghui Wang, Yutong Hou, Yuting Ning, Junjie Hou, Ruimei Wang, Qian Li, Xueshan Xia   +8 more
doaj   +1 more source

Evidence for interspecies transmission of oyster herpesvirus in marine bivalves [PDF]

Journal of General Virology, 2001
Since 1991, numerous herpesvirus infections associated with high mortality have been reported around the world in various marine bivalve species. In order to determine whether these infections are due to ostreid herpesvirus-1 (OsHV1), a previously characterized pathogen of the Japanese oyster (Crassostrea gigas), PCR analysis was carried out on 30 ...
Arzul, Isabelle, Renault, Tristan, Lipart, Cécile, Davison, Andrew   +3 more
openaire   +2 more sources

Gardiquimod Nanoemulsion Targets Cutaneous Leishmaniasis Lesions Reducing Systemic Toxicity and Parasite Burden

Advanced Healthcare Materials, EarlyView.
Nanoemulsion delivery of a TLR7 agonist enhances safety and promotes colocalization with Leishmania‐infected macrophages in skin lesions, enabling a ∼2‐log reduction in parasite burden. However, tissue‐level constraints and TLR‐driven regulatory feedback generate a mixed immune response that limits complete parasite clearance.
Carmen Palomino‐Cano, M. Carmen Mera‐Delgado, Esther Moreno, Esther Larrea, Lecnia Aguirre, Jonathan Miguel Zanatta, Sónia Barros‐Carvalho, Iola F. Duarte, Ricardo Silvestre, Juan M. Irache, Javier Carrión, Socorro Espuelas   +11 more
wiley   +1 more source

Molecular Basis of Barriers for Interspecies Transmissibility of Mammalian Prions [PDF]

Molecular Cell, 2004
Spongiform encephalopathies are believed to be transmitted by a unique mechanism involving self-propagating conformational conversion of prion protein into a misfolded form. Here we demonstrate that fundamental aspects of mammalian prion propagation, including the species barrier and strain diversity, can be reproduced in vitro in a seeded ...
Vanik, David L, Surewicz, Krystyna A, Surewicz, Witold K   +2 more
openaire   +2 more sources

Mitochondrial Carrier SLC25A13 Drives Ferroptosis Resistance and Immune Evasion via a STAT3–IFI6 Circuit in Breast Cancer

Advanced Science, EarlyView.
SLC25A13 is identified as an immunometabolic driver of triple‐negative breast cancer that sustains ferroptosis resistance and immune evasion through a STAT3–IFI6 circuit. Pharmacologic degradation of SLC25A13 restores ferroptosis sensitivity and enhances anti‐PD‐1 efficacy, highlighting a strategy to convert immune‐cold tumors into immunotherapy ...
Yingze Zhu, Yuhan Tang, Yingcui Chen, Zhuoqi Zhang, Yige Lu, Xinyue Wang, Qiyuan Shi, Wenhui Zhao, Hui Pang   +8 more
wiley   +1 more source

Structure of the β2‐α2 loop and interspecies prion transmission

The FASEB Journal, 2012
ABSTRACT Prions are misfolded, aggregated conformers of the prion protein that can be transmitted between species. The precise determinants of interspecies transmission remain unclear, although structural similarity between the infectious prion and host prion protein is required for efficient conversion to the ...
Bett, Cyrus *equal contribution, Fernández-Borges, Natalia *equal contribution, Kurt, Timothy D., Lucero, Melanie, Nilsson, K. Peter R., Castilla, Joaquin, Sigurdson, Christina J.   +6 more
openaire   +3 more sources

Microplastics‐Induced Gut Microbiota Dysbiosis Accelerates Alzheimer's‐Like Pathology and Cognitive Decline via the Gut–Brain Axis

Advanced Science, EarlyView.
Microplastics (MPs) breach the gut‐brain axis by triggering taurine‐depleting microbiota dysbiosis that accelerates Alzheimer‐like pathology in 5XFAD mice. Taurine supplementation normalizes autophagy, microglial quiescence, and cognition, and plasma taurine inversely tracks cognitive decline in ADNI participants, revealing a readily translatable ...
Zifeng Wu, Jiarong Yang, Miaoxuan Zhang, Yi Li, Zhuling Tu, Ji Wang, Jin‐Tai Yu, Kun Guo, Rongcan Luo   +8 more
wiley   +1 more source

Experimental Infection and Natural Contact Exposure of Dogs with Avian Influenza Virus (H5N1)

Emerging Infectious Diseases, 2008
Experiments that exposed influenza virus (H5N1)–infected cats to susceptible dogs did not result in intraspecies or interspecies transmission. Infected dogs showed increased body temperatures, viral RNA in pharyngeal swabs, and seroconversion but not ...
Matthias Giese, Timm C. Harder, Jens P. Teifke, Robert Klopfleisch, Angele Breithaupt, Thomas C. Mettenleiter, Thomas W. Vahlenkamp   +6 more
doaj   +1 more source