Results 51 to 60 of about 79,018 (278)

Multimodal AI‐Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1

Advanced Science, EarlyView.
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin, Wenzhuo Xu, Kang Liu, Ping Wang, Zhenzhen Zhu, Wenyu Lu, Zhe Zheng, Xiaoqian Peng, Xunkai Yin, Shulan Mei, An Pan, Jian Liu, Lihong Hu   +12 more
wiley   +1 more source

Profiling Localized Immunomodulation and Drug Biodistribution within a Subcutaneous Vascularized Niche for Cell Transplantation

Advanced Science, EarlyView.
We studied how five common immunosuppressants behave when delivered directly to a transplant site instead of systemically. Using a vascularized implant for islet transplantation, we show that local delivery protects grafts, limits drug spread to the rest of the body, and produces distinct immune signatures.
Jocelyn Nikita Campa‐Carranza, Simone Capuani, Melissa A. Willman, Alexander Rabassa, Ashley L. Joubert, Tommaso Bo, Letizia Franco, Marzia Conte, Ana L. Anaya‐García, Gabrielle E. Rome, Rim Ouni, Henry J. Seaborne, Camden A. Caffey, Dora M. Berman, Junjun Zheng, Jesus Paez‐Mayorga, Corrine Ying Xuan Chua, Shu Hsia Chen, Norma S. Kenyon, Alessandro Grattoni   +19 more
wiley   +1 more source

Effects of interspecific competition on the growth of macrophytes and nutrient removal in constructed wetlands: A comparative assessment of free water surface and horizontal subsurface flow systems [PDF]

, 2016
© 2016 Elsevier Ltd. The outcome of competition between adjoining interspecific colonies of Phragmites and Typha in two large field pilot-scale free water surface (FWS) and subsurface flow (SSF) CWs is evaluated.
Dzakpasu, M, Ge, Y, Guo, W, Ngo, HH, Wang, X, Xiong, J, Zhao, Y, Zheng, Y   +7 more
core   +1 more source

Influence of Temperature on the Interaction for Resource Utilization between Fall Armyworm, Spodoptera frugiperda (Lepidoptera: Noctuidae), and a Community of Lepidopteran Maize Stemborers Larvae

Insects, 2020
Intra- and interspecific interactions within communities of species that utilize the same resources are characterized by competition or facilitation.
Bonoukpoè Mawuko Sokame, François Rebaudo, Peter Malusi, Sevgan Subramanian, Dora Chao Kilalo, Gerald Juma, Paul-André Calatayud   +6 more
doaj   +1 more source

Alien plant fitness is limited by functional trade‐offs rather than a long‐term increase in competitive effects of native communities

Ecology and Evolution, 2023
Alien plants experience novel abiotic conditions and interactions with native communities in the introduced area. Intra‐ and interspecific selection on functional traits in the new environment may lead to increased population growth with time since ...
Marco R. Brendel, Frank M. Schurr, Christine S. Sheppard   +2 more
doaj   +1 more source

Soil, competition, and niche shifts shape the floral mosaic of an annual plant diversity hotspot

American Journal of Botany, EarlyView.
Abstract Premise Plant species with affinity for harsh substrates often have well‐defined edaphic (soil) niches and are ideal for exploring questions of community assembly. Vertic clay soils are chemically and physically challenging to plant establishment and productivity, and annual plant communities associated with these soils of the San Joaquin ...
Emma R. Fryer, Ryan O'Dell, Dena L. Grossenbacher, Alyssa Shon, Skyler McKinnon, Nishanta Rajakaruna   +5 more
wiley   +1 more source

Are there morpho‐acoustic patterns of adaptation in nonhuman primate ears? Testing the role of ecology and habitat in shaping ear morphology and function

The Anatomical Record, EarlyView.
Abstract Analysis of the variation in the bony structures of the inner and middle ear provides critical insights into functional morphology, as well as adaptive morphology across primates. In this study, we investigated whether ear morphology patterns are related to the ecological characteristics of species and their habitats to test two acoustic ...
Myriam Marsot, Rémi Laffont, Émilie Steimetz, Patricia Balaresque, Sébastien Couette   +4 more
wiley   +1 more source

Interspecific association of brown trout (Salmo trutta) with non-native brook trout (Salvelinus fontinalis) at the fry stage [PDF]

, 2017
The introduction of non-native brook trout (Salvelinus fontinalis) in Europe has led to displacement and decreasing populations of native brown trout (Salmo trutta).
Johnsson, Jörgen I., Koeck, Barbara, Lovén Wallerius, Magnus, Näslund, Joacim   +3 more
core   +1 more source

The importance of aboveground and belowground interspecific interactions in determining crop growth and advantages of peanut/maize intercropping

Crop Journal, 2021
Intercropping of maize (Zea mays L.) and peanut (Arachis hypogaea L.) often results in greater yields than the respective sole crops. However, there is limited knowledge of aboveground and belowground interspecific interactions between maize and peanut ...
Nianyuan Jiao, Jiangtao Wang, Chao Ma, Chaochun Zhang, Dayong Guo, Fusuo Zhang, Erik Steen Jensen   +6 more
doaj   +1 more source

Description of the skull, braincase, and dentition of Moschognathus whaitsi (Dinocephalia, Tapinocephalia), and its palaeobiological and behavioral implications

The Anatomical Record, EarlyView.
Abstract A subadult Moschognathus whaitsi from the Eastern Cape Province, South Africa, was scanned using synchrotron radiation X‐ray computed tomography (SRXCT). Its subadult state allowed the cranial bones and teeth to be identified and individually reconstructed in 3D.
Tristen Lafferty, Luke A. Norton, Aliénor Duhamel, Julien Benoit   +3 more
wiley   +1 more source