Results 1 to 10 of about 21,422 (233)

Stress - its effects on health and behavior: a guide for practitioners [PDF]

, 2014
KEY POINTS Stress may affect the physical, mental, and social health of an animal. The effect of stressors is individual to the animal concerned and results from the appraisal of the stressor by the animal.
Karagiannis, Christos, Mills, Daniel, Zulch, Helen   +2 more
core   +1 more source

A central role for Toll-like 4 receptors in interstitial cystitis? [PDF]

, 2018
[Extract] Interstitial cystitis/bladder pain syndrome (IC/BPS) remains a clinical enigma. Estimated to affect over 8 million women globally, it is a challenge to diagnose and to treat effectively, due to an unknown etiology and complex, poorly understood
Chess-Williams, Russ, McDermott, Catherine, Sellers, Donna Jayne   +2 more
core   +1 more source

Recognizing myofascial pelvic pain in the female patient with chronic pelvic pain. [PDF]

, 2012
Myofascial pelvic pain (MFPP) is a major component of chronic pelvic pain (CPP) and often is not properly identified by health care providers. The hallmark diagnostic indicator of MFPP is myofascial trigger points in the pelvic floor musculature that ...
Katzman, Wendy B, Pastore, Elizabeth A
core   +1 more source

Imatinib Mesylate Reduces Neurotrophic Factors and pERK and pAKT Expression in Urinary Bladder of Female Mice With Cyclophosphamide-Induced Cystitis

Frontiers in Systems Neuroscience, 2022
Imatinib mesylate is a tyrosine kinase inhibitor that inhibits platelet-derived growth factor receptor (PDGFR)-α, -β, stem cell factor receptor (c-KIT), and BCR-ABL.
Megan Perkins, Beatrice M. Girard, Susan E. Campbell, Grant W. Hennig, Margaret A. Vizzard   +4 more
doaj   +1 more source

Urinary alkalisation for uncomplicated urinary tract infection (Protocol) [PDF]

, 2013
This is the protocol for a review and there is no abstract. The objectives are as follows:We aim to look at the benefits and harms of the use of urinary alkalisers for the treatment of uncomplicated UTIs in adult ...
Bleidorn, Brumfitt, Burian, Carlsson, Foxman, Foxman, Franz, Gupta, Higgins, Mazzulli, Munday, Richards, Spooner, Zhanel   +13 more
core   +1 more source

Notch1 Signaling Contributes to Mechanical Allodynia Associated with Cyclophosphamide-Induced Cystitis by Promoting Microglia Activation and Neuroinflammation

Mediators of Inflammation, 2021
Aims. Notch1 signaling regulates microglia activation, which promotes neuroinflammation. Neuroinflammation plays an essential role in various kinds of pain sensation, including bladder-related pain in bladder pain syndrome/interstitial cystitis (BPS/IC).
Jialiang Chen, Honglu Ding, Bolong Liu, Xiangfu Zhou, Xin Zhou, Zhijun Lin, Fei Yang, Hailun Zhan, Hengjun Xiao   +8 more
doaj   +1 more source

Modulation of lower urinary tract smooth muscle contraction and relaxation by the urothelium [PDF]

, 2018
The epithelial inner layer of the lower urinary tract, i.e., the urothelium, and other parts of the mucosa are not just a passive barrier but play an active role in the sensing of stretching, neurotransmitters, paracrine mediators, hormones, and growth ...
Chess-Williams, Russ, Michel, Martin C., Sellers, Donna   +2 more
core   +1 more source

Gut microbiota and interstitial cystitis: exploring the gut-bladder axis through mendelian randomization, biological annotation and bulk RNA sequencing

Frontiers in Immunology
BackgroundSeveral observational studies have indicated an association between interstitial cystitis and the composition of the gut microbiota; however, the causality and underlying mechanisms remain unclear.
Chaowei Fu, Yu Zhao, Xiang Zhou, Jing Lv, Shengkai Jin, Yuhua Zhou, Fengping Liu, Ninghan Feng, Ninghan Feng   +8 more
doaj   +1 more source

Metabolomics Insights Into Pathophysiological Mechanisms of Interstitial Cystitis [PDF]

, 2014
Interstitial cystitis (IC), also known as painful bladder syndrome or bladder pain syndrome, is a chronic lower urinary tract syndrome characterized by pelvic pain, urinary urgency, and increased urinary frequency in the absence of bacterial infection or
Fiehn, Oliver, Kim, Jayoung
core   +4 more sources

Personal cell therapy for interstitial cystitis with autologous stromal vascular fraction stem cells

Therapeutic Advances in Urology, 2019
Background: The objective of this study was to evaluate whether autologous stem-cell-based therapy may mitigate the symptoms of interstitial cystitis. Methods: Stromal vascular fraction (SVF) rich in stem cells and derived from autologous adipose tissue ...
Elliot B. Lander, Mark H. Berman, Jackie R. See   +2 more
doaj   +1 more source