Results 131 to 140 of about 162,220 (306)
Comparison of the pathogenicity of multiple SARS‐CoV‐2 variants in mouse models
Animal Models and Experimental Medicine, EarlyView.We assessed the pathogenicity of various SARS‐CoV‐2 variants using two distinct mouse models. Our findings indicated that earlier variants, including WH‐09, Beta, and Delta, exhibited greater pathogenicity than later variants. Specifically, the Omicron variant demonstrated reduced pathogenicity, characterized by a shorter disease course and diminished ...
Qi Lv +12 more
wiley +1 more source
In vivo levels and in vitro production of interferon-gamma in fibrosing interstitial lung diseases
, 1992 C. Prior, P L Haslam
openalex +2 more sources
Diosgenin ameliorates silica‐induced tuberculosis in rats
Animal Models and Experimental Medicine, EarlyView.Silicosis increases susceptibility to tuberculosis due to impaired macrophage function and oxidative stress. This study demonstrates that diosgenin, a steroidal saponin, significantly inhibits Mycobacterium smegmatis (IC₅₀ = 0.006 μg/mL), reduces lung fibrosis, and restores antioxidant enzyme levels (↑SOD, ↑CAT, ↓MDA) in silica‐exposed rats ...
Williams Asamoah Adu +5 more
wiley +1 more source
Development of an efficient mice model of cancer‐associated cardiac cachexia
Animal Models and Experimental Medicine, EarlyView.This work establishes a preclinical framework for targeting ubiquitin pathways to mitigate the morbidity of cancer‐related cardiopathy. Our integrated approach delineates a hierarchical progression from subcellular dysfunction to macroscopic cardiac deterioration. These findings mechanistically link tumor‐induced cachexia to cardiac dysfunction through
Shijie Xiong +9 more
wiley +1 more source
USE OF SEQUENTIAL DTPA CLEARANCE AND HIGH RESOLUTION COMPUTERIZED TOMOGRAPHY EN MONITORING INTERSTITIAL LUNG DISEASE IN DERMATOMYOSITTS [PDF]
, 1996 C. Hill, E. Romas, Bruce Kirkham
openalex +1 more source
Advances on Albumin‐Based Carriers for Anticancer Drug Delivery
Advanced NanoBiomed Research, EarlyView.This study systematically classifies the drug delivery modes of albumin by examining the characteristics of its surface‐active groups and internal binding sites. It provides an in‐depth analysis of various drug delivery strategies and their corresponding targeting mechanisms.
Ruoli Zhou +4 more
wiley +1 more source
Engineered Hydrogels Revolutionize Locoregional Cancer Immunotherapy
Advanced NanoBiomed Research, EarlyView.This review systematically summarizes the latest research progress on injectable hydrogels in cancer immunotherapy, highlighting their unique advantages in precise immune activation, local drug‐controlled release, and immune microenvironment remodeling. These features provide innovative solutions to overcome the bottlenecks of systemic side effects and
Jiyong Wei +3 more
wiley +1 more source
Functions of alveolar macrophages in patients with interstitial lung diseases.
, 1990 Shigee Hosoya +9 more
openalex +2 more sources
Exercise Testing in Patients With Interstitial Lung Disease: To the Editor [PDF]
, 1998 R. Loddenkemper
openalex +1 more source