CYP2C19 Genotype is Associated with Citalopram Treatment Outcomes in a Real‐World Setting
Clinical Pharmacology &Therapeutics, EarlyView.CYP2C19 metabolizes various selective serotonin reuptake inhibitors (SSRIs) and genetic CYP2C19 variants are associated with SSRI tolerability and response. Yet, whether CYP2C19 variability also impacts citalopram response remained unclear. We here evaluated associations between CYP2C19 genotypes and citalopram prescription data of 11,079 patients from
Yoomi Park +2 more
wiley +1 more source
Time of week intensity estimation from partly interval censored data with applications to police patrol planning. [PDF]
J Appl StatTian J, Porter MD.
europepmc +1 more source
Repurposing Drugs for Malaria through a Human Dose Prediction: A Case Study with Berzosertib
Clinical Pharmacology &Therapeutics, EarlyView.Repurposing drugs whose clinical safety has been established offers a valuable approach to reduce the cost and time associated with the development of new drugs for malaria. Here, we investigate the potential to repurpose the anticancer kinase inhibitor berzosertib for the treatment of malaria, by assessing whether a predicted efficacious human dose ...
Devasha Redhi +5 more
wiley +1 more source
Group lasso priors for Bayesian accelerated failure time models with left-truncated and interval-censored data. [PDF]
Stat Methods Med ResReeder HT, Haneuse S, Lee KH.
europepmc +1 more source
Estimation of the force of infection and infectious period of skin sores in remote Australian communities using interval-censored data. [PDF]
PLoS Comput Biol, 2020 Lydeamore MJ +11 more
europepmc +1 more source
A latent spatial piecewise exponential model for interval-censored disease surveillance data with time-varying covariates and misclassification [PDF]
, 2018 Yaxuan Sun +5 more
openalex +1 more source
The Visual Predictive Check and Real‐World Data
Clinical Pharmacology &Therapeutics, EarlyView.The visual predictive check (VPC) is a standard tool for assessing pharmacometric model suitability, producing visualizations that compare observed data with simulated data such that both model structure and model variability terms can be assessed. However, real‐world data commonly reflect clinical decision‐making that adapts therapy in response to ...
Jasmine H. Hughes +2 more
wiley +1 more source
Bayesian transformation model for spatial partly interval-censored data. [PDF]
J Appl StatQiu M, Hu T.
europepmc +1 more source
Estimation in the single change-point hazard function for interval-censored data with a cure fraction. [PDF]
J Appl Stat, 2020 Wang B, Wang X, Song L.
europepmc +1 more source