Results 101 to 110 of about 1,986,111 (289)

Ekeland’s variational principle for interval-valued functions with an α-level set in Kaleva-Seikkala’s type fuzzy metric spaces

Demonstratio Mathematica
In this paper, we establish a new version of Ekeland’s variational principle in the setting of Kaleva-Seikkala’s type fuzzy metric spaces, where the objective function is an interval-valued function defined on a fuzzy metric space, and the perturbation ...
Liu Xuan, He Fei, Lu Ning
doaj   +1 more source

On Solving Bi-objective Interval Valued Neutrosophic Assignment Problem [PDF]

Neutrosophic Sets and Systems
The assignment problem (AP) is a well-researched combinatorial optimization problem in which the overall assignment cost or time is minimized by assigning multiple items (tasks) to several entities (workers).
T.K. Buvaneshwari, D. Anuradha
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Caputo gH-differentiability for Gronwalls inequality: insight, new results and application

Journal of Inequalities and Applications
This paper investigates Gronwall’s inequality within the framework of interval-valued functions under Caputo gH-differentiability. Employing interval-valued Caputo fractional derivatives and associated interval-valued Riemann–Liouville integrals, we ...
Fatima Khan, Anum Zehra, Muhammad Farman, Kottakkaran Sooppy Nisar, Aceng Sambas, Mohamed Hafez   +5 more
doaj   +1 more source

Bi-Objective Optimization for Interval Max-Plus Linear Systems

Mathematics
This paper investigates the interval-valued-multi-objective-optimization problem, whose objective function is a vector-valued max-plus interval function and the constraint function is a real-affine function.
Cailu Wang, Jiye Zhang, Pengcheng Chen, Haichao Zhao   +3 more
doaj   +1 more source

General admissibly ordered interval-valued overlap functions

, 2021
Supported by the Spanish Ministry of Science and Technology (PC093-094 TFIPDL, TIN2016-81731-REDT, TIN2016-77356-P (AEI/FEDER, UE)), Spanish Ministry of Economy and Competitiveness through the Spanish National Research (project PID2019-108392GB-I00 / AEI / 10.13039/501100011033), UPNA (PJUPNA1926), CNPq (311429/2020-3, 301618/2019-4) and FAPERGS (19 ...
Asmus, Tiago, Pereira Dimuro, Graçaliz, Sanz Delgado, José Antonio, Wieczynski, Jonata, Lucca, Giancarlo, Bustince Sola, Humberto   +5 more
openaire   +2 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source