Results 81 to 90 of about 1,986,111 (289)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Interval-valued Pythagorean fuzzy multi-criteria decision-making method based on the set pair analysis theory and Choquet integral

Complex & Intelligent Systems, 2022
This paper proposes a novel fuzzy multi-criteria decision-making method based on an improved score function of connection numbers and Choquet integral under interval-valued Pythagorean fuzzy environment.
Feng Li, Jialiang Xie, Mingwei Lin
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Some fundamental theorems in the interval-valued functions and time scales [PDF]

Journal of Mahani Mathematical Research
This research investigates the topological structure of the space of interval-valued functions equipped with an order relation defined by open balls. The aim is to establish analogues of fundamental theorems in calculus, including Bolzano’s theorem, the ...
Tahere Shokoohi, Seyed Mohammad Sadegh Modarres Mosadegh, Azam Karami   +2 more
doaj   +1 more source

Fuzzy multicriteria decision making method based on the improved accuracy function for interval-valued intuitionistic fuzzy sets

Soft Computing - A Fusion of Foundations, Methodologies and Applications, 2015
A new accuracy function for the theory of interval-valued intuitionistic fuzzy set, which overcomes some difficulties arising in the existing methods for determining rank of interval-valued intuitionistic fuzzy numbers, is proposed by taking into account
Rıdvan Şahin
semanticscholar   +1 more source

Implication Functions in Interval-Valued Fuzzy Set Theory [PDF]

, 2013
Interval-valued fuzzy set theory is an extension of fuzzy set theory in which the real, but unknown, membership degree is approximated by a closed interval of possible membership degrees. Since implications on the unit interval play an important role in fuzzy set theory, several authors have extended this notion to interval-valued fuzzy set theory ...
openaire   +2 more sources

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Significant Study of Fuzzy Fractional Inequalities with Generalized Operators and Applications

Fractal and Fractional
There are many techniques for the extension and generalization of fractional theories, one of which improves fractional operators by means of their kernels.
Rana Safdar Ali, Humira Sif, Gauhar Rehman, Ahmad Aloqaily, Nabil Mlaiki   +4 more
doaj   +1 more source