Results 91 to 100 of about 3,879,270 (279)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Geometrical-based algorithm for variational segmentation and smoothing of vector-valued images
, 2007 An optimisation method based on a nonlinear functional is considered for segmentation and smoothing of vector-valued images. An edge-based approach is proposed to initially segment the image using geometrical properties such as metric tensor of the ...
Sharif, Bayan, Mahmoodi, Sasan
core +2 more sources
Abstract homogeneity of interval-valued functions [PDF]
, 2023 In this paper we develop the idea of abstract homogeneity in the context of interval-valued (IV) functions endowed with admissible orders and investigate some of its properties.Comment: 2 ...
Santiago, Regivan +6 more
core +1 more source
Ostrowski and Čebyšev type inequalities for interval-valued functions and applications. [PDF]
PLoS One, 2023 Guo J, Zhu X, Li W, Li H.
europepmc +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Vector valued logarithmic residues and the extraction of elementary factors [PDF]
An analysis is presented of the circumstances under which, by the extraction of elementary factors, an analytic Banach algebra valued function can be transformed into one taking invertible values only. Elementary factors are generalizations of the simple
Bart, H., Silbermann, B., Ehrhardt, T.
core
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
A NOTE ON THE MONOTONE INTERVAL-VALUED SET FUNCTION DEFINED BY THE INTERVAL-VALUED CHOQUET INTEGRAL [PDF]
Communications of the Korean Mathematical Society, 2007 At first, we consider nonnegative monotone interval-valued set functions and nonegative measurable interval-valued functions. In this paper we investigate some properties and structural characteristics of the monotone interval-valued set function defined by an interval-valued Choquet integral.
openaire +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source