Results 171 to 180 of about 75,980 (291)

A Prospective, Multicenter, Open Label Study Investigating the Implementation of a Standardized Algorithm for Coronary CaLcificatiOn With PlaquE Modification Using UltraSound Guidance to Improve Procedural and Clinical Outcomes (CYCLOPES): Design and Rationale of the CYCLOPES Trial

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Introduction Moderate‐to‐severe calcification is present in ~20%–30% of patients undergoing coronary angiography. Coronary lesion modification is often necessary to facilitate optimal stent delivery and expansion, with several dedicated devices now approved for calcium modification before stent implantation. The CYCLOPES study aims to evaluate
Daniel O'Callaghan, Rory Durand, Colm G. Hanratty, Thomas Cuisset, Beatriz Vaquerizo, Jan‐Malte Sinning, Peter O'Kane, J. J. Coughlan, Simon Walsh, Róisín Colleran, Himanshu Rai, Osama Soliman, Emanuele Barbato, Barbara E. Stähli, Robert A. Byrne   +14 more
wiley   +1 more source

Interval censoring and competing risks when reporting results of glaucoma surgery. [PDF]

Eye (Lond), 2014
Kivelä T, Kujala E, Forsman E, Vesti E.
europepmc   +1 more source

Clinical Impact of Angiographic Complications Occurring During Percutaneous Coronary Interventions

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background The clinical impact of different types of angiographic complications during elective PCIs remains largely unexplored. Aims To explore the incidence, management, and outcomes of angiographic complications by type and severity during non‐urgent, non‐CTO PCIs. Methods Clinical and procedural characteristics were prospectively collected
Emiliano Bianchini, Mattia Lunardi, Fabio Casamassima, Francesco Bianchini, Mattia Basile, Enrico Romagnoli, Cristina Aurigemma, Lazzaro Paraggio, Francesco Fracassi, Rocco Antonio Montone, Antonino Buffon, Luigi Cappannoli, Carolina Ierardi, Tommaso Sanna, Antonio Maria Leone, Carlo Trani, Francesco Burzotta   +16 more
wiley   +1 more source

Emulating Six Cardiovascular Outcome Trials of Antidiabetic Drugs in Individuals with Type 2 Diabetes: Analyses Based on Real‐World Databases from Korea and Taiwan

Clinical Pharmacology &Therapeutics, EarlyView.
With the increasing volume of clinical evidence derived from large‐scale Asian real‐world data (RWD) and the growing interest in its use in regulatory decision‐making, it is important to conduct benchmarking exercises that evaluate whether studies using Asian RWD can generate similar conclusions as randomized controlled trials (RCTs).
Hwa Yeon Ko, Philip C. M. Au, Michael Chun‐Yuan Cheng, Ching‐Lung Cheung, Ahhyung Choi, Miyuki Hsing‐Chun Hsieh, Han Eol Jeong, Edward Chia‐Cheng Lai, Brian Meng‐Hsun Li, Kenneth K. C. Man, Jeremy A. Rassen, Daniel Hsiang‐Te Tsai, Shirley V. Wang, Ian C. K. Wong, Ju‐Young Shin, Sohee Park   +15 more
wiley   +1 more source

Considerations for Estimating Causal Effects of Informatively Timed Treatments. [PDF]

Epidemiology
Oganisian A.
europepmc   +1 more source

Prognostic Implication of CYP2C19 Genotype According to Clinical Risk Stratification After Drug‐Eluting Stent Implantation

Clinical Pharmacology &Therapeutics, EarlyView.
From the nationwide multicenter consortium, 8,163 patients undergoing drug‐eluting stent implantation were classified according to the presence of the CYP2C19 loss‐of‐function (LoF) allele: rapid or normal metabolizers (RMs/NMs) vs. intermediate or poor metabolizers (IMs/PMs), and clinical risk was stratified using the CHADS‐P2A2RC and TRS 2°P scores ...
Hyun Woong Park, Jae‐Hwan Lee, Jin‐Ok Jeong, Diana A. Gorog, Udaya S. Tantry, Byeong‐Keuk Kim, Hyung Joon Joo, Kiyuk Chang, Jin‐Yong Hwang, Young Bin Song, Sung Gyun Ahn, Jung‐Won Suh, Woong Gil Choi, Jung Rae Cho, Jeehoon Kang, Sang Yeub Lee, Hyo‐Soo Kim, Moo Hyun Kim, Do‐Sun Lim, Eun‐Seok Shin, Paul A. Gurbel, Young‐Hoon Jeong, on behalf of the PTRG‐DES Consortium Investigators   +22 more
wiley   +1 more source

Lower Dose‐Normalized Tacrolimus Exposure in CYP3A5*6 vs. *3 Loss‐of‐Function Allele Carriers: A Longitudinal Retrospective Real‐World Study in Kidney Transplant Recipients

Clinical Pharmacology &Therapeutics, EarlyView.
Pharmacogenomic research has historically focused on individuals of European ancestry, leading to the underrepresentation of genetic variants common in non‐European populations. This bias is exemplified by CYP3A5*6, a functionally consequential variant common in individuals of African ancestry (MAF: 11–19%) but virtually absent in Europeans (MAF: 0.15%)
Amar D. Levens, Dirk Jan A. R. Moes, Yanick Boer, Aiko P. J. de Vries, Dorottya K. de Vries, Danny van der Helm, Soufian Meziyerh, Dave L. Roelen, Stefan Böhringer, Teun Van Gelder, Jesse J. Swen   +10 more
wiley   +1 more source

Discrete-time neural Markov models. [PDF]

BMC Med Res Methodol
Sundell J, Wahlquist Y, Soltesz K.
europepmc   +1 more source

Longitudinal Tumor Size and Survival Modeling for Exposure–Response Analysis of Drugs with Frequent Dose Reductions: Dose Justification of Abemaciclib in Patients with Metastatic Breast Cancer

Clinical Pharmacology &Therapeutics, EarlyView.
Abemaciclib is an oral anticancer drug indicated for treatment of HR+ HER2‐ breast cancer. Dose modifications due to side effects are frequent, thus drug exposures change over time as a result of altering the dose or temporarily withholding abemaciclib treatment.
Emmanuel Chigutsa, Sonya C. Chapman, P. Kellie Turner   +2 more
wiley   +1 more source

A practical overview and statistical analysis of interval-censored data in cancer. [PDF]

Cancer Commun (Lond)
Dey T, Lipsitz S, Cooper Z, Sinha D, Trinh QD, Cole A, Clinton TN.   +6 more
europepmc   +1 more source