Results 71 to 80 of about 363,612 (293)

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Robust Interval State Estimation for Distribution Systems Considering Pseudo-measurement Interval Prediction

Journal of Modern Power Systems and Clean Energy
Interval state estimation (ISE) can estimate state intervals of power systems according to confidence intervals of predicted pseudo-measurements, thereby analyzing the impact of uncertain pseudo-measurements on states.
Xu Zhang, Wei Yan, Meiqing Huo, Hui Li
doaj   +1 more source

INTERVAL ESTIMATION OF WEIBULL DISTRIBUTION BASED ON MODIFIED PIVOTAL VARIABLE METHOD (MT)

Jixie qiangdu, 2023
To solve the problems of complex calculation and weak applicability of the traditional interval estimation methods such as Weibull distribution with the different parameters, a simple interval estimation method suitable to the conditions of multi ...
XUE GuangMing, NING Peng, FU YaoYu, HE HongRui, ZHOU Jun   +4 more
doaj  

High LRIG1 expression predicts lymph node metastasis in patients with uterine cervical cancer

FEBS Open Bio, EarlyView.
Lymph node status is crucial in determining treatment for women with early‐stage cervical cancer. We demonstrate that high LRIG1 protein expression in primary tumors can predict lymph node metastases. Our findings support further investigation of LRIG1 as a biomarker to improve staging accuracy and guide treatment decisions in cervical cancer patients.
Pernilla Israelsson, Lisa Lif, Husam Oda, Alexandra Lorenzzi de Melo, David Lindquist, Håkan Hedman   +5 more
wiley   +1 more source

Interval State Estimation of Distribution Network With Power Flow Constraint

IEEE Access, 2018
Currently, distribution network is faced with many problems, e.g., low automation coverage and less data acquisition. There are also lots of challenges in state estimation, such as imprecise approximation of network parameters and measurement devices as ...
Zhi Wu, Huiyu Zhan, Wei Gu, Shujiang Zheng, Bojiang Li   +4 more
doaj   +1 more source

Patient Selection in Deep Brain Stimulation: A Role for Transcranial Direct Current Stimulation to Enhance the Levodopa Challenge?

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Dopaminergic medication and deep brain stimulation (DBS) improve motor symptoms in Parkinson's disease (PD), but levodopa response alone may not predict DBS outcomes. We retrospectively analyzed 19 PD patients undergoing levodopa challenges with and without prior transcranial direct current stimulation targeting a defined PD response network ...
Lukas L. Goede, Patricia Zvarova, Bahne H. Bahners, Andreas Horn   +3 more
wiley   +1 more source

CSF Biomarker‐Based Cognitive Trajectories in Parkinson's Disease‐Subjective Cognitive Decline

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive complaints without objective cognitive impairment in Parkinson's Disease, termed Parkinson's Disease‐Subjective Cognitive Decline (PD‐SCD), have been associated with cognitive decline. However, its progression is heterogeneous, highlighting the need for improved identification of patients at greater risk for deterioration ...
Jon Rodriguez‐Antiguedad, Arnau Puig‐Davi, Iñigo Ruíz‐Barrio, Javier Pagonabarraga, Anna Vázquez‐Oliver, Andrea Horta‐Barba, Jaime Kulisevsky, Saül Martínez‐Horta   +7 more
wiley   +1 more source

Application of interval state estimation in vehicle control

Alexandria Engineering Journal, 2022
This paper mainly attempts to design an interval observer for vehicle dynamic system, and make interval observation of the state for moving vehicles. For this purpose, a novel robust estimation method was introduced to apply interval state estimation in ...
Zhaoxia Huang
doaj  

Coffee Consumption Is Associated With Later Age‐at‐Onset of Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Observation studies suggest that coffee consumption may lower the risk and delay the age‐at‐onset (AAO) of Parkinson's disease (PD). The aim of this study was to explore the causal relationship and genetic association between coffee consumption and the AAO, risk, and progression of PD. Using Mendelian randomization, we identified a significant
Dariia Kuzovenkova, Lang Liu, Ziv Gan‐Or, Konstantin Senkevich   +3 more
wiley   +1 more source

On Interval Estimation of a Ranked Parameter

Journal of the Royal Statistical Society Series B: Statistical Methodology, 1974
Summary Let F(x; θ) denote a family of distributions on the real line, indexed by the real-valued parameter θ. It is assumed that the given family is stochastically increasing in θ, that is, F(x; θ) is non-increasing in θ for each x. Let θ  l …, θk represent k unknown values of the parameter θ, and let X  l …, Xk represent k independent ...
K. Alam, K. M. Lal Saxena
openaire   +3 more sources