Results 81 to 90 of about 1,327,202 (268)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Continuous Belief Functions: Focal Intervals Properties [PDF]

open access: yes, 2012
The set of focal elements resulting from a conjunctive or disjunctive combination of consonant belief functions is regretfully not consonant and is thus very difficult to represent. In this paper, we propose a graphical representation of the cross product of two focal sets originating from univariate Gaussian pdfs.
openaire   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Supervised Classification High-Resolution Remote-Sensing Image Based on Interval Type-2 Fuzzy Membership Function

open access: yesRemote Sensing, 2018
Because of the degradation of classification accuracy that is caused by the uncertainty of pixel class and classification decisions of high-resolution remote-sensing images, we proposed a supervised classification method that is based on an interval type-
Chunyan Wang, Aigong Xu, Xiaoli Li
doaj   +1 more source

Use of the Confidence Interval function

open access: yesEpidemiology, 1990
Graphics displaying all confidence intervals around a point estimate have been referred to as P-value functions and consonance intervals. We recommend use of the term confidence interval function (CI function) rather than P-value function. The CI function is useful because it simultaneously depicts point estimation, variability, and the relation of ...
K M, Sullivan, D A, Foster
openaire   +3 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Implementation and verification of global optimization benchmark problems

open access: yesOpen Engineering, 2017
The paper considers the implementation and verification of a test suite containing 150 benchmarks for global deterministic box-constrained optimization. A C++ library for describing standard mathematical expressions was developed for this purpose.
Posypkin Mikhail, Usov Alexander
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Interval conjectures for level Hilbert functions

open access: yesJournal of Algebra, 2009
We conjecture that the set of all Hilbert functions of (artinian) level algebras enjoys a very natural form of regularity, which we call the {\em Interval Conjecture} (IC): If, for some positive integer $ $, $(1,h_1,...,h_i,...,h_e)$ and $(1,h_1,...,h_i+ ,...,h_e)$ are both level $h$-vectors, then $(1,h_1,...,h_i+ ,...,h_e)$ is also level for each ...
openaire   +2 more sources

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