Results 261 to 270 of about 226,666 (311)

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Dissecting the Ecological Structure of Health and Disease in the Global Gut Microbiome

Advanced Science, EarlyView.
We introduce Wiredancer, a framework that identifies three continuous ecological factors of the gut microbiota. These factors exhibit distinct patterns across health and disease, jointly capturing disrupted ecological stability and offering a new perspective for precision diagnostics and therapeutic strategies.
Baoyuan Zhu, Shuhao Chen, Yunheng Diao, Wei Wang, Yuanyuan Huang, Liqin Liang, Xiaodan Lu, Rui Han, Minxin Guo, Zhaobo Li, Shuhong Wang, Hehua Li, Chenyu Liu, Jing Zhou, Dongsheng Xiong, Xiaobo Li, Yuping Ning, Xuetao Shi, Fengchun Wu, Kai Wu   +19 more
wiley   +1 more source

Blind Identification of Altered Functional Subnetworks in Alzheimer's Disease Using Resting-State fMRI. [PDF]

Biomed Eng Comput Biol
Keyvanfard F, Nasiraei-Moghaddam A.
europepmc   +1 more source

Supraphysiological Doses of Vitamin A Promote Changes in Hippocampal Oscillation Bands and Cardiac Activity in Wistar Rats. [PDF]

ACS Omega
Hartcopff PFP, Lins A, de Araujo DB, Barbosa GB, de Souza LV, Hamoy MKO, Eiró-Quirino L, de Lima SMA, Muto NA, Lopes DCF, Hamoy M.   +10 more
europepmc   +1 more source

Topology modeling and energy efficiency prediction of parallel chillers based on deep learning. [PDF]

Sci Rep
Liu Y, Yang X, Zhang L, Tian Y.
europepmc   +1 more source

Nonintrusive Power Load Decomposition Based on Adaptive Graph Convolutional Neural Network. [PDF]

Sensors (Basel)
Zhao P, Wei J, Wang L, Qiu Y.
europepmc   +1 more source

Macrolide Resistance of <i>Mycoplasma pneumoniae</i> Among Children in Hangzhou: A 2024-2025 Post-Pandemic Surveillance Study. [PDF]

Infect Drug Resist
Xu X, Xiao X, Zhou J, Zhao X.
europepmc   +1 more source