Results 91 to 100 of about 448,992 (178)

Single‐Cell and Spatial Transcriptomic Profiling of Penile Squamous Cell Carcinoma Reveals Dynamics of Tumor Differentiation and Immune Microenvironment

Advanced Science, EarlyView.
This study uses single‐nucleus RNA sequencing and spatial transcriptomics to investigate penile squamous cell carcinoma (PSCC). It reveals that PSCC tumor cells mimic normal penile epithelium differentiation, independent of HPV status. The Tum_1 subtype shows basal stem‐like characteristics and promotes invasiveness. HPV‐positive basal stem‐like tumors
Hongjian Song, Zhichao Tong, Guixiang Xie, Yaowei Li, Yubo Zhao, Fengpu Fan, Zongzheng Yang, Qing Shi, Qian Zhang, Feng Wen, Hongxue Meng, Haonan Li, Pengyu Guo, Dayong Hou, Zhenwei Zhang, Zhihao Yin, Ziyi Liu, Jianwei Wang, Peng Zhang, Peng Dai, Changfu Li, Lichen Teng, Yangyang Xu, Dexin Ding, Tao Xu, Jianzhang Li, Yongsheng Chen, Yu Qiu, XiaoWei Hu, Wentao Liu, Liang Wu, Roman Nawroth, Guibo Li, Hang Su, Ziqing Deng, Ziqi Wang, Di Wang, Wanhai Xu   +37 more
wiley   +1 more source

Wiener index application in intuitionistic fuzzy rough graphs for transport network flow. [PDF]

Sci Rep
Shaik N, Shaik SB.
europepmc   +1 more source

Interference Pattern Caused by Bilateral Bone Conduction Stimulation Impairs Sound Localization

Advanced Science, EarlyView.
This work explores how crosstalk‐induced wave interference affects bone conduction (BC) sound localization. Using a theoretical model, cadaveric vibrometry, and psychoacoustic tests, atypical BC lateralization patterns are revealed that contradict air conduction (AC) principles.
Liu‐Jie Ren, Yi Yu, Cheng Hua, You‐Zhou Xie, Wen‐Juan Yao, Jun‐Yi Liang, Chen‐Long Li, Tian‐Yu Zhang   +7 more
wiley   +1 more source

Enhancing security in electromagnetic radiation therapy using fuzzy graph theory. [PDF]

Sci Rep
Lal R, Singh RK, Nishad DK, Khalid S.
europepmc   +1 more source

Hybrid Series of Carbon‐Vacancy Electrodes for Multi Chemical Vapors Diagnosis Using a Residual Multi‐Task Model

Advanced Science, EarlyView.
This study presents a graphene oxide‐based gas sensor array integrated with a deep learning framework for precise detection and classification of multiple gases. By combining advanced sensing materials and a 1D‐ResNet architecture, the system achieves high sensitivity and accuracy, demonstrating its potential for real‐time environmental monitoring ...
Tianci Liu, Yun Ji Hwang, Lu Zhang, Jongwoo Hong, Teajong Hwang, Seong Chan Jun   +5 more
wiley   +1 more source

Refining the Allostatic Self-Efficacy Theory of Fatigue and Depression Using Causal Inference. [PDF]

Entropy (Basel)
Hess AJ, von Werder D, Harrison OK, Heinzle J, Stephan KE.   +4 more
europepmc   +1 more source

Oxytocin‐Mediate Modulation of Splenic Immunosuppression in Chronic Social Stress Through Neuroendocrine Pathways

Advanced Science, EarlyView.
Chronic social stress elevates oxytocin levels, leading to immunosuppression by enhancing regulatory T‐cell activity and promoting anti‐inflammatory macrophage polarization in the spleen. Blocking oxytocin signaling reverses these effects but worsens stress‐induced behavioral disorders and reduces survival rates. This highlights oxytocin's dual role in
Yi‐Shu Zhang, Hai‐Chao Chen, Jia‐Xin Cao, Si‐Wei Zhou, Yue‐Zhang Ma, Yu‐Hong Jing   +5 more
wiley   +1 more source

Distributed Consensus Control for Discrete-Time T-S Fuzzy Multiple-Agent Systems Based on an Unknown Input Observer. [PDF]

Sensors (Basel)
Ling X, Xu H, Weng W, Zhu F.
europepmc   +1 more source

Mechanical Load‐Induced Upregulation of Talin2 through Non‐Canonical Deubiquitination of OTUB1 Drives Facet Joint Osteoarthritis Pathogenesis

Advanced Science, EarlyView.
Facet joint osteoarthritis (FJOA), prevalent in the elderly, involves Talin2 upregulation promoting ECM degradation while suppressing synthesis. Mechanical load stabilizes Talin2 via OTUB1‐mediated non‐canonical deubiquitination, driving CCL2 expression that recruits immune cells, exacerbating inflammatory joint degeneration.
Yizhen Huang, Heng Sun, Haojie Chen, Xiangpeng Wang, Junduo Zhao, Yang Jiao, Hongyi Zhou, Haoyu Cai, Jiafeng Dai, Xuan Huang, Weiyun Chen, Jianxiong Shen   +11 more
wiley   +1 more source

The Effect of Dopaminergic Therapy in Parkinson's Disease: A Graph Theory Analysis. [PDF]

Brain Sci
Siva K, Ponnusamy P, Chavda V, Montemurro N.   +3 more
europepmc   +1 more source