Results 41 to 50 of about 479,648 (240)
A Graph Theory Approach for Regional Controllability of Boolean Cellular Automata
, 2019 Controllability is one of the central concepts of modern control theory that allows a good understanding of a system's behaviour. It consists in constraining a system to reach the desired state from an initial state within a given time interval. When the
Bagnoli, Franco +3 more
core +3 more sources
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
On singular probability densities generated by extremal dynamics
, 2004 Extremal dynamics is the mechanism that drives the Bak-Sneppen model into a (self-organized) critical state, marked by a singular stationary probability density $p(x)$.
Bak +23 more
core +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Time estimation and beta segregation: An EEG study and graph theoretical approach. [PDF]
PLoS ONE, 2018 Elucidation of the neural correlates of time perception constitutes an important research topic in cognitive neuroscience. The focus to date has been on durations in the millisecond to seconds range, but here we used electroencephalography (EEG) to ...
Amir Hossein Ghaderi +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Spectral analysis of the matrix Sturm–Liouville operator
Boundary Value Problems, 2019 The self-adjoint matrix Sturm–Liouville operator on a finite interval with a boundary condition in general form is studied. We obtain asymptotic formulas for the eigenvalues and the weight matrices of the considered operator.
Natalia P. Bondarenko
doaj +1 more source
Scientific Reports, 2023 In fear conditioning with time intervals between the conditioned (CS) and unconditioned (US) stimuli, a neural representation of the CS must be maintained over time to be associated with the later US.
Thays Brenner Santos +3 more
doaj +1 more source