Results 121 to 130 of about 157,845 (305)

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li   +11 more
wiley   +1 more source

A Reduction of the Graph Reconstruction Conjecture

open access: yesDiscussiones Mathematicae Graph Theory, 2014
A graph is said to be reconstructible if it is determined up to isomor- phism from the collection of all its one-vertex deleted unlabeled subgraphs. Reconstruction Conjecture (RC) asserts that all graphs on at least three vertices are reconstructible. In
Monikandan S., Balakumar J.
doaj   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Transit functions on graphs (and posets)

open access: yes
The notion of transit function is introduced to present a unifying approachfor results and ideas on intervals, convexities and betweenness in graphs andposets.
Mulder, H.M.
core  

Interval Graphs

open access: yes, 2016
We examine the problem of counting interval graphs. We answer the question posed by Hanlon, of whether the formal power series generating function of the number of interval graphs on n vertices has a positive radius of convergence.
Yang, Joyce C
core  

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit   +11 more
wiley   +1 more source

Polynomial Time Algorithm for Shortest Paths in Interval Temporal Graphs

open access: yesAlgorithms
We develop a polynomial time algorithm for the single-source all destinations shortest paths problem for interval temporal graphs (ITGs). While a polynomial time algorithm for this problem is known for contact sequence temporal graphs (CSGs), no such ...
Anuj Jain, Sartaj Sahni
doaj   +1 more source

End Simplicial Vertices in Path Graphs

open access: yesDiscussiones Mathematicae Graph Theory, 2016
A graph is a path graph if there is a tree, called UV -model, whose vertices are the maximal cliques of the graph and for each vertex x of the graph the set of maximal cliques that contains it induces a path in the tree.
Gutierrez Marisa, Tondato Silvia B.
doaj   +1 more source

Median computation in graphs using consensus strategies

open access: yes
Following the Majority Strategy in graphs, other consensus strategies, namely Plurality Strategy, Hill Climbing and Steepest Ascent Hill Climbing strategies on graphs are discussed as methods for the computation of median sets of profiles.
Changat, M.   +2 more
core  

Electroencephalographic Normalization as a Biomarker of Clinical Recovery in Down Syndrome Regression Disorder

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Down syndrome regression disorder is a syndrome characterized by subacute loss of cognitive, behavioral, and functional abilities in individuals with Down syndrome. Electroencephalography abnormalities are frequently observed during evaluation, but it remains unclear whether these findings represent a dynamic marker of disease ...
Jonathan D. Santoro   +14 more
wiley   +1 more source

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