Advanced Science, EarlyView.ABSTRACT Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti‐inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate.
Liwei Liu +15 more
wiley +1 more source
Why is it easier to predict the epidemic curve than to reconstruct the underlying contact network? [PDF]
J Math BiolKeliger D, Horváth I.
europepmc +1 more source
Advanced Science, EarlyView.We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel +16 more
wiley +1 more source
MAISNet: a multi-species integrated graph neural network for acetylcholinesterase inhibitor screening. [PDF]
BioinformaticsShao D, Liang S, Xiong Y, Liang G.
europepmc +1 more source
Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq
Advanced Science, EarlyView.Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su +10 more
wiley +1 more source
Evolution Equations on Co-evolving Graphs: Long-Time Behaviour and the Graph-Continuity Equation. [PDF]
J Nonlinear SciCarrillo JA, Esposito A, Mikolás L.
europepmc +1 more source
Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs
Advanced Science, EarlyView.Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou +22 more
wiley +1 more source
Polystyrene nanoplastics promotes inflammation and aging in young mice through the oral-gut microbiome axis. [PDF]
Front ImmunolWang Y, Dong C, Xiao Y.
europepmc +1 more source
Reaching accuracy declines with postural demand during whole-body leaning. [PDF]
Front Sports Act LivingFujimura T, Hagio S, Kouzaki M.
europepmc +1 more source
Post-selection inference for causal effects after causal discovery. [PDF]
BiometrikaChang TH, Guo Z, Malinsky D.
europepmc +1 more source