Results 101 to 110 of about 9,914,882 (388)

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

The Spinal Instability Neoplastic Score correlates with epidural spinal cord compression -a retrospective cohort of 256 surgically treated patients with spinal metastases

BMC Musculoskeletal Disorders
Background Bone metastases can compromise the integrity of the spinal canal and cause epidural spinal cord compression (ESCC). The Spinal Instability Neoplastic Score (SINS) was developed in order to evaluate spinal instability due to a neoplastic ...
Lukas Bobinski, Joel Axelsson, Jonathan Melhus, Josefin Åkerstedt, Johan Wänman   +4 more
doaj   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Rare earth - no case for government intervention [PDF]

China has officially restricted exports of rare earth for several years and announced this year it will further tighten exports. Rare earth is a group of 17 different metals, usually found clustered together.
Georg Zachmann
core   +1 more source

The long-term impact of the MEMA kwa Vijana adolescent sexual and reproductive health intervention: effect of dose and time since intervention exposure. [PDF]

, 2011
BACKGROUND: Despite recent decreases in HIV incidence in many sub-Saharan African countries, there is little evidence that specific behavioural interventions have led to a reduction in HIV among young people.
AM Doyle, Aoife M. Doyle, D Kirby, D Meekers, DA Ross, DA Ross, David A. Ross, Deborah Watson-Jones, E Lagarde, FM Cowan, Helen A. Weiss, John Changalucha, K Wellings, Kaballa Maganja, P Maharaj, R Dixon-Mueller, R Hayes, R Magnani, R Monasch, R Wang, Richard J. Hayes, RJ Hayes, S Napierala Mavedzenge, S Yusuf, Saidi Kapiga, Sheena McCormack, Sten H. Vermund, UN, UNAIDS, WHO, X Sun, YB Cheung   +31 more
core   +3 more sources

Conflict-related trauma and bereavement: exploring differential symptom profiles of prolonged grief and posttraumatic stress disorder

BMC Psychiatry, 2017
Background Exposure to trauma and bereavement is common in conflict-affected regions. Previous research suggests considerable heterogeneity in responses to trauma and loss with varying symptom representations.
Carina Heeke, Nadine Stammel, Manuel Heinrich, Christine Knaevelsrud   +3 more
doaj   +1 more source

The care transitions intervention: results of a randomized controlled trial.

Archives of Internal Medicine, 2006
BACKGROUND Patients with complex care needs who require care across different health care settings are vulnerable to experiencing serious quality problems.
E. Coleman, C. Parry, Sandra A Chalmers, Sung‐joon Min   +3 more
semanticscholar   +1 more source

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

Support and intervention arrangements [PDF]

, 2013
Nottingham Trent University's Emergency Services Research Unit have been carrying out research into the new National Framework for Fire and Rescue Services since the former Fire Minister Bob Neill announced a strategic review of the framework shortly ...
Greenhalgh, K, Murphy, P
core