Results 241 to 250 of about 10,658,076 (388)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Persevering or quitting? A systematic review of adherence and dropout in nutrition and exercise interventions for sarcopenic obesity. [PDF]

Asia Pac J Clin Nutr
Zhang J, Wang Y, Shen M, Chen P, Wang Q, Yu K.   +5 more
europepmc   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Feasibility of a Psychoeducational Intervention for Empowering Parents to Optimise Feeding Practices in China: A Randomised Controlled Feasibility Trial. [PDF]

Matern Child Nutr
Wang J, Chang YS, Wei X, Cao Y, Winkley K.   +4 more
europepmc   +1 more source

A multidisciplinary intervention to prevent the readmission of elderly patients with congestive heart failure.

New England Journal of Medicine, 1995
M. Rich, V. Beckham, C. Wittenberg, C. Leven, K. Freedland, R. Carney   +5 more
semanticscholar   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

A multifactorial intervention to reduce the risk of falling among elderly people living in the community.

New England Journal of Medicine, 1994
M. Tinetti, D. Baker, G. McAvay, Elizabeth B. Claus, P. Garrett, Margaret Gottschalk, M. L. Koch, Kathryn M Trainor, R. Horwitz   +8 more
semanticscholar   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Cardiovascular Effects of Intensive Lifestyle Intervention in Type 2 Diabetes

Current Atherosclerosis Reports, 2014
C. Johnston, J. Moreno, J. Foreyt
semanticscholar   +1 more source

Compassion Fatigue in Mental Health Nurses: Understanding Cause, Effect, Prevention and Intervention

, 2016
Anne Kathrin Funk
openalex   +1 more source