Results 251 to 260 of about 10,658,076 (388)

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Effect of computerized physician order entry and a team intervention on prevention of serious medication errors.

Journal of the American Medical Association (JAMA), 1998
D. Bates, L. Leape, D. Cullen, N. Laird, L. Petersen, J. Teich, E. Burdick, M. Hickey, S. Kleefield, B. Shea, M. Vander Vliet, D. Seger   +11 more
semanticscholar   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Exploring the Effects of a Yoga Intervention on Stress and Coping Self-Efficacy on People Living With HIV: A Randomized Controlled Trial. [PDF]

J Nurs Res
Hidayat J, Chen MY, Liu CY, Liu WI, Chen KM, Chiou PY, Pfeiffer S.   +6 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A Multi-Level Intervention to Address Childhood Obesity in Rural Hispanic Communities. [PDF]

Obes Sci Pract
Ko LK, Rillamas-Sun E, Kratz M, Jimenez E, Jang SH, Mendoza JA, Bishop S, Xiao L.   +7 more
europepmc   +1 more source

Long-Term Effects of Lifestyle Interventions Targeting Diabetes and Weight Loss on Aging-Related Outcomes [PDF]

Peter J. Huckfeldt, Kristine E. Ensrud
openalex   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

The added value of an internet-based intervention for treatment of aggression in forensic psychiatric outpatients: A mixed-methods pilot randomized controlled trial. [PDF]

Digit Health
Kip H, Klein Haneveld L, Klooster IT, Kelders SM.   +3 more
europepmc   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source