Results 51 to 60 of about 149,072 (298)

Effectiveness of a Theory- and Web-Based Adaptive Implementation Intervention on Nurses’ and Nursing Students’ Intentions to Provide Brief Counseling: Protocol for a Randomized Controlled Trial

JMIR Research Protocols, 2020
BackgroundBrief counseling can motivate patients to initiate health behavior change. However, increasing the provision of brief counseling by nurses is difficult due to contextual and practitioner-level factors impeding nurses’ motivation and intentions ...
Fontaine, Guillaume, Cossette, Sylvie, Gagnon, Marie-Pierre, Dubé, Véronique, Côté, José   +4 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

A pilot sequential multiple assignment randomized trial for developing a biobehavioral adaptive intervention to improve insulin sensitivity in patients with stage 1 obesity

Pilot and Feasibility Studies
Background Intervention packages targeting obesity-related conditions often include multiple behavioral and pharmacological components, yet the independent and synergistic effects of these strategies on disease progression remain largely unexplored ...
Aseel El Zein, Katie M. Ellison, Julianne G. Clina, Chelsi Reynolds, Caroline W. Cohen, James O. Hill, Gareth R. Dutton, Tapan S. Mehta, R. Drew Sayer   +8 more
doaj   +1 more source

KONSELING KARIR DENGAN MENGGUNAKAN CAREER INFORMATION-PROCESSING MODEL UNTUK MEMBANTU CAREER DECISION-MAKING

Psympathic: Jurnal Ilmiah Psikologi, 2017
Having graduated from senior high school, most of high school students continue their education to university level. This research aimed to find effectiveness of career counseling by using career information-processing model to assist career decision ...
Fatma Nur Aqmarina, Riana Sahrani, Rahmah Hastuti   +2 more
doaj   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Effect of Infertility Counseling on the Quality of Life of infertile Couples: A Randomized Clinical Trial

Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2021
Background & Aim: Infertility is defined as inability to become pregnant with regular sexual intercourse for more than one year without using preventive methods. Infertility has negative effects on the quality of life of infertile couples.
Tayebeh Mokhtari Sorkhani, Katayoun Alidousti, Atefeh Ahmadi, Moghaddameh Mirzaee, Victoria Habibzadeh   +4 more
doaj  

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Tailored System to Deliver Behavioral Intervention and Manage Data in Randomized Trials

Journal of Medical Internet Research, 2013
BackgroundThe integrity of behavioral intervention trials depends on consistent intervention delivery, and uniform, comprehensive process data collection.
Zheng, Hua, Rosal, Milagros C, Oatis, Carol A, Li, Wenjun, Franklin, Patricia D   +4 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source