Results 81 to 90 of about 3,571,652 (340)

A pilot sequential multiple assignment randomized trial for developing a biobehavioral adaptive intervention to improve insulin sensitivity in patients with stage 1 obesity

Pilot and Feasibility Studies
Background Intervention packages targeting obesity-related conditions often include multiple behavioral and pharmacological components, yet the independent and synergistic effects of these strategies on disease progression remain largely unexplored ...
Aseel El Zein, Katie M. Ellison, Julianne G. Clina, Chelsi Reynolds, Caroline W. Cohen, James O. Hill, Gareth R. Dutton, Tapan S. Mehta, R. Drew Sayer   +8 more
doaj   +1 more source

The Outcome of A Counseling Intervention. The Experience of the Counseling Service UPO

European Psychiatry, 2017
Background.Counseling addresses the emotional social, work, school and physical health concerns that people may have at different stages in their lives. It focuses on typical life stresses and more severe issues. It may be addressed to individuals, groups, organisations.Aim and methods.The objective of our study was to assess the outcome of a ...
E. Gattoni, D. Ponzetti, Alessandro Rossi, Eleonora Gambaro, C. Gramaglia, P. Zeppegno   +5 more
openaire   +2 more sources

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

Tailored System to Deliver Behavioral Intervention and Manage Data in Randomized Trials

Journal of Medical Internet Research, 2013
BackgroundThe integrity of behavioral intervention trials depends on consistent intervention delivery, and uniform, comprehensive process data collection.
Zheng, Hua, Rosal, Milagros C, Oatis, Carol A, Li, Wenjun, Franklin, Patricia D   +4 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Effect of Infertility Counseling on the Quality of Life of infertile Couples: A Randomized Clinical Trial

Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2021
Background & Aim: Infertility is defined as inability to become pregnant with regular sexual intercourse for more than one year without using preventive methods. Infertility has negative effects on the quality of life of infertile couples.
Tayebeh Mokhtari Sorkhani, Katayoun Alidousti, Atefeh Ahmadi, Moghaddameh Mirzaee, Victoria Habibzadeh   +4 more
doaj  

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

PENGARUH KONSELING TERHADAP PENGETAHUAN DAN SIKAP PEMBERIAN MP-ASI

Media Gizi Indonesia, 2016
Growth failure process started since the child was still in the womb. The success of growth process is determined by feeding practices. A total of 59% of Indonesian children aged 6-23 months were given food that inappropriate with the recommendations of ...
Margareta Fatimah Azzahra, Lailatul Muniroh   +1 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source