Results 91 to 100 of about 4,048,647 (310)

An integrated general practice and pharmacy-based intervention to promote the use of appropriate preventive medications among individuals at high cardiovascular disease risk: protocol for a cluster randomized controlled trial [PDF]

, 2016
Background: Cardiovascular diseases (CVD) are responsible for significant morbidity, premature mortality, and economic burden. Despite established evidence that supports the use of preventive medications among patients at high CVD risk, treatment gaps ...
Adina Hayek, Anthony Rodgers, Antithrombotic Trialists’ Collaboration, Antithrombotic Trialists’ Collaboration, Anushka Patel, B Mitchell, B Patel, Baldeep Kaur, Bandana Saini, BL Carter, BL Svarstad, BL Svarstad, Blood Pressure Lowering Treatment Trialists' Collaboration, C Armour, C Baigent, Carol Armour, Charlotte Hespe, Christopher Reid, D Peiris, D Peiris, D Peiris, David Peiris, DE Morisky, DE Morisky, DM Wentzlaff, DP Peiris, E Hatah, EL Heeley, Fred Hersch, GF Moore, Ines Krass, JK Lee, KL Margolis, Louise Shiel, M Krousel-Wood, MP Morgado, N Houston Miller, P Ho, R Webster, RB Haynes, RJ Webster, Rohina Joshi, Ruth Webster, S Jan, S Michie, Serigne Lo, Stephen Jan, Tim Usherwood, Tracey-Lea Laba, WK Kellogg Foundation, World Health Organisation   +50 more
core   +4 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Exploring the barriers and facilitators to volunteering as an intervention for those with long‐term neurological conditions: How make therapeutic volunteering possible?

Health Expectations
Background Volunteering may have therapeutic benefits, but little is known about its requirements and potential for people with neurological conditions (pwNC). Design Two separate focus groups were conducted in Darmstadt, Germany: one group consisting of
Helene Eisenhut, Johnny Collett, Farzaneh Yazdani   +2 more
doaj   +1 more source

'It just wasn’t going to be heard’: A mixed methods study to compare different ways of involving people with diabetes and health‐care professionals in health intervention research

Health Expectations, 2020
Background Guidelines recommend involving intervention users in the intervention development process. However, there is limited guidance on how to involve users in a meaningful and effective way.
Emmy Racine, Fiona Riordan, Eunice Phillip, Grainne Flynn, Sheena McHugh, Patricia M. Kearney   +5 more
doaj   +1 more source

Environmental ethics [PDF]

, 2009
Reynolds highlights three dimensions of environmental ethics – normative, philosophical and political – in the context of a long-standing controversial development initiative for dam constructions in the Narmada river valley in India. In discussing these
Reynolds, Martin
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Optimising the value of the evidence generated in Implementation Science : the use of ontologies to address the challenges [PDF]

, 2017
Our thanks to Marta Marques, Emma Norris, Ildiko Tombor, Holly Walton, Olga Perski and Hilary Groarke for comments on an earlier draft of this editorial.
Johnston, Marie, Michie, Susan
core   +3 more sources

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

The Future of EU Cohesion Policy. Endogenous Development – Added Value of Intervention – Regulatory Frameworks [PDF]

, 2012
The successful operation of the regional development – or cohesion – policy of the European Union has a strategic importance from the point of view of the whole integration process.
Kengyel, Ákos
core