Results 111 to 120 of about 4,048,647 (310)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Impacts of early intervention with fluoxetine following early neonatal immune activation on depression-like behaviors and body weight in mice [PDF]

Several reports have suggested that early neonatal immune activation adversely influences the hypothalamic– pituitary–adrenal (HPA) axis development in humans and animal models.
امانی, محمد, ببری, شیرین, بختیاری, امیر, دوستی, محمد حسین, زارع, پیمان, سالاری, علی اکبر, مجیدی ذوالبنین, نعیمه   +6 more
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

RURAL TOURISM: DEVELOPMENT, PUBLIC INTERVENTION AND LESSONS FROM THE ISRAELI EXPERIENCE [PDF]

Community/Rural/Urban Development,
Finkelshtain, Israel, Fleischer, Aliza, Tchetchik, Anat   +2 more
core   +1 more source

Developing reading comprehension for children with Autism Spectrum Disorder through concrete representations : a thesis presented in partial fulfilment of the requirements for the degree of Masters of Educational Psychology at Massey University, Albany, New Zealand [PDF]

, 2016
The ability to comprehend written text is an essential skill for all students, leading to their increased engagement at school, and the development of communication and cognitive skills.
Serci, Amanda
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Development and reporting of a specialised antenatal music therapy intervention using the MRC framework and TIDieR checklist

Frontiers in Psychiatry
IntroductionPerinatal mental health can significantly impact parental and infant wellbeing. Music interventions have shown promise in improving perinatal wellbeing during pregnancy.
Pui Sze Cheung, Pui Sze Cheung, Pui Sze Cheung, Pui Sze Cheung, Sylvia Murphy Tighe, Sylvia Murphy Tighe, Mas Mahady Mohamad, Mas Mahady Mohamad, Triona McCaffrey, Triona McCaffrey   +9 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Developing mHealth interventions

, 2023
The general aim of this thesis was threefold. Firstly, it aimed to design an innovativetheory- and evidence-based mHealth intervention to reduce CVD risk. Second, it setout to implement it in a manner that resonates with its intended audience. Third, itaimed to evaluate the short-term effects of the resulting intervention.
openaire   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source