Results 111 to 120 of about 5,012,135 (297)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Using Intervention Mapping for Program Design and Production of iCHAMPSS: An Online Decision Support System to Increase Adoption, Implementation, and Maintenance of Evidence-Based Sexual Health Programs

Frontiers in Public Health, 2017
In Texas and across the United States, unintended pregnancy, HIV, and sexually transmitted infections (STIs) among adolescents remain serious public health issues.
Melissa F. Peskin, Belinda F. Hernandez, Efrat K. Gabay, Paula Cuccaro, Dennis H. Li, Eric Ratliff, Kelly Reed-Hirsch, Yanneth Rivera, Kimberly Johnson-Baker, Susan Tortolero Emery, Ross Shegog   +10 more
doaj   +1 more source

Enhancing the social capital in industrial workplaces: Developing workplace interventions using intervention mapping.

Evaluation and Program Planning, 2019
Social capital in the workplace has been found to be associated with employee wellbeing and work engagement. Yet, evidence of effects of interventions to enhance the social capital are lacking.
A. Meng, V. Borg, T. Clausen
semanticscholar   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Formative Research to Develop a Lifestyle Application (App) for African American Breast Cancer Survivors

Journal of the Georgia Public Health Association, 2016
Background: There is a proliferation of lifestyle-oriented mobile technologies; however, few have targeted users. Through intervention mapping, investigators and community partners completed Steps 1-3 (needs assessment, formulation of change objectives ...
Selina Smith, Mary Whitehead, Joyce Sheats, Brittney Fontenot, Ernest Alema-Mensah, Benjamin Ansa   +5 more
doaj   +1 more source

Social cognition remediation interventions: A systematic mapping review

PLOS ONE, 2019
Impairments in social cognition have been described in several psychiatric and neurological disorders. Given the importance of the relationship between social cognition and functioning and quality of life in these disorders, there is a growing interest in social cognition remediation interventions.
Patricia Fernández-Sotos, Iosune Torio, Antonio Fernández-Caballero, Elena Navarro, Pascual González, Mónica Dompablo, Roberto Rodriguez-Jimenez   +6 more
openaire   +4 more sources

Development of an improvisational music therapy intervention for young adults with depressive symptoms: An intervention mapping study

The Arts in Psychotherapy, 2019
Depression is a highly prevalent and seriously impairing disorder. Evidence suggests that music therapy can decrease depression, though the music therapy that is offered is often not clearly described in studies.
S. Aalbers, A. Vink, Ruth E. Freeman, Kim Pattiselanno, M. Spreen, S. V. Hooren   +5 more
semanticscholar   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Developing a Return to Work Intervention for Breast Cancer Survivors with the Intervention Mapping Protocol: Challenges and Opportunities of the Needs Assessment

Frontiers in Public Health, 2018
Return to work (RTW) is an important step for breast cancer survivors (BCSs). However, they face many barriers that affect particularly women with low socioeconomic status (SES). Health care, workplace, and insurance actors lack knowledge and collaborate
Jean-Baptiste Fassier, Jean-Baptiste Fassier, Marion Lamort-Bouché, Marion Lamort-Bouché, Guillaume Broc, Laure Guittard, Laure Guittard, Julien Péron, Julien Péron, Sabrina Rouat, Julien Carretier, Béatrice Fervers, Béatrice Fervers, Laurent Letrilliart, Laurent Letrilliart, Philippe Sarnin   +15 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source