Results 151 to 160 of about 4,020,664 (302)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Training and Clinical Preparation of Nurses Delivering Cognitive Behavioral Therapy: A Systematic Review. [PDF]

Worldviews Evid Based Nurs
Zusman N, Bekman N.
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Lay health-worker delivered and technology-based interventions for sexual and reproductive health among adolescents and young adults in low- and middle-income countries: a scoping review. [PDF]

BMJ Open
Kern M, Neumann C, Bosompim B, Sujata S, Mayeden S, Moshi FV, Ann D, Mauti J, Kurniawan AL, Dlamini NC, Nabukeera S, Machanyangwa S, Tewahido D, Shinde S, Bärnighausen T, Mwanyika-Sando M, Anaba EA, Bukenya J, DASH collaborators.   +18 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Relevance of improved reporting for non-pharmacological interventions in clinical trials: Bridging research to clinical practice. [PDF]

Braz J Phys Ther
Alburquerque-Sendín F, Rodrigues-de-Souza DP.   +1 more
europepmc   +1 more source

Modest policy interventions [PDF]

The authors present a theoretical and empirical framework for computing and evaluating linear projections conditional on hypothetical paths of monetary policy.
Tao Zha, Eric M. Leeper
core  

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

TAVR in a patient with an anomalous left main: Self-expanding prosthesis might be the preferred choice

Hellenic Journal of Cardiology, 2020
Georgios Tzanis, Marco Ancona, Vittorio Romano, Barbara Bellini, Fabio Sgura, Matteo Montorfano   +5 more
doaj   +1 more source

Efficacy, Effectiveness, and Efficiency of Nurse-Led Interventions: Insights From a Critical Systematic Review. [PDF]

Nurs Inq
Fontanals-Jimenez A, Trapero-Bertran M, Insa-Calderón E.   +2 more
europepmc   +1 more source