Results 151 to 160 of about 4,116,152 (307)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

How Nurses Assess Interventions to Promote Patients Sleep on Hospital Wards: Results of a Self-Report Survey. [PDF]

Scand J Caring Sci
Vasse M, Paala E, Kangasniemi M, Koivunen M.   +3 more
europepmc   +1 more source

Foreign Exchange Interventions Under Inflation Targeting: The Czech Experience [PDF]

This paper discusses the role of foreign exchange interventions in the inflation-targeting regime, focusing on the Czech experience since 1998. It proposes criteria for assessing whether the interventions are consistent with the inflation targeting ...
Tomas Holub
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The Effect of Behavioral Interventions That Include Goal Setting on Pain, Disability, and Physical Activity in People With Chronic Musculoskeletal Pain: A Systematic Review and Meta-Analysis. [PDF]

Clin J Pain
Natoli AR, Gibbs MT, Mishra I, Devonshire J, O'Brien-Smith J, McAuley JH, Cashin AG, Jones MD, Jones MD.   +8 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Key Characteristics and Mechanisms in Ventilator Weaning of Adult Intensive Care Patients-A Qualitative Study With Healthcare Professionals. [PDF]

Nurs Crit Care
Sterr F, Bauernfeind L, Kepplinger A, Rester C, Palm R, Metzing S.   +5 more
europepmc   +1 more source

An analysis of Japanese foreign exchange interventions, 1991-2002 [PDF]

The effectiveness of Japanese interventions over the past decade depended in large part on the frequency and size of the transactions. Prior to June 1995, Japanese interventions only had value as a forecast that the previous day's yen appreciation or ...
Owen F. Humpage, Alain P. Chaboud
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

A Scoping Review on Decision-Making Interventions for Kidney Failure Treatment Options by the Kidney Disease Aging Research Collaborative. [PDF]

J Am Geriatr Soc
Clark-Cutaia MN, Mittleman I, Magro J, Butler CR, Ghildayal N, Kimberly L, Klitenic S, Kurella Tamura M, Ozdemir S, Washington TR, Wilson M, McAdams-DeMarco M, Hall RK, Kidney Disease Aging Research Collaborative.   +13 more
europepmc   +1 more source