Results 201 to 210 of about 5,445,753 (311)

The Effect of Family Voice Interventions on Delirium Incidence and Duration in Adult ICU Patients: A Systematic Review and Meta-Analysis. [PDF]

Nurs Crit Care
Peschel E, Diegelmann M, Eßl-Maurer R, Goetze P, Krotsetis S, Neumann-Wagner A, Oh E, Schmidt-Maciejewski B, Schimböck F, Vater V, Nydahl P.   +10 more
europepmc   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

From Innovation to Infrastructure: Why Digital Behavioral Health Still Struggles to Scale.

J Med Internet Res
van Mierlo T.
europepmc   +1 more source

De-implementation of healthcare interventions post-COVID-19: evidence from the Evidence-Based Interventions (EBI) programme in England. [PDF]

BMJ Open
Glynn J, Jones T, Bell M, Blazeby JM, Burton C, Conefrey C, Donovan J, Farrar N, Morley J, McNair AG, Owen-Smith A, Rule E, Thornton G, Tucker V, Williams I, Rooshenas L, Hollingworth W.   +16 more
europepmc   +1 more source

Feed interventions to sustainably increase cows’ productivity [PDF]

, 2020
Osele, Vivien, Paul, Birthe K.
core  

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Effectiveness of mHealth Interventions for Improving eHealth Literacy Among Patients With Chronic Diseases: Meta-Analysis and Systematic Review.

J Med Internet Res
Yang X, Ma Y, Wang Y, Liu M, Liu X, Jiao X, Yan F, Ma Y, Han L, Zhang Y.   +9 more
europepmc   +1 more source

Comparative effects of some pharmacological and non-pharmacological interventions on cognitive function in Alzheimer's disease: A Bayesian network meta-analysis. [PDF]

J Prev Alzheimers Dis
Zhao Y, Luo G, Huang C, Chen Z, Wei Y, Chen Q, Wang F, Gan Y, Yin X.   +8 more
europepmc   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source