Results 281 to 290 of about 84,616 (318)

Modern concepts of intervertebral disc degeneration

Voprosy neirokhirurgii imeni N.N. Burdenko, 2020
The widespread prevalence of degenerative spine diseases and achievements in the treatment of these lesions have not yet led to an answer the main question: «What is the etiology of spine degeneration?» Treatment will remain symptomatic if primary cause of disease will be unclear. However, improvement of genetic and molecular survey gradually clarifies
A O, Gushcha, A R, Yusupova
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Pathogenesis of Intervertebral Disc Degeneration

2013
It is estimated that as much as 84 % of the population will suffer from low back pain (LBP) at some point in their lifetime (Walker 2000), with around 10 % of sufferers being chronically disabled. As such LBP is one of the most prevalent musculoskeletal conditions affecting Western society (Stewart et al.
Hoyland, JA, Richardson, Stephen, Freemont, AJ   +2 more
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MMPs and ADAMTSs in intervertebral disc degeneration

Clinica Chimica Acta, 2015
Intervertebral disc degeneration (IDD) is the most common diagnosis in patients with low back pain, a leading cause of musculoskeletal disability worldwide. The major components of extracellular matrix (ECM) within the discs are type II collagen (Col II) and aggrecan.
Wen-Jun, Wang, Xiao-Hua, Yu, Cheng, Wang, Wei, Yang, Wen-Si, He, Shu-Jun, Zhang, Yi-Guo, Yan, Jian, Zhang   +7 more
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The role of estrogen in intervertebral disc degeneration

Steroids, 2020
Intervertebral disc degeneration (IVDD) is a main contributor to low back and radicular pain, which imposes heavy economic burdens on society. However, the etiology and mechanism of IVDD are complex and still not completely clear. In particular, the role of estrogen in IVDD has not received much attention in recent research, although estrogen plays a ...
Lin-Yu, Jin, Xiao-Xing, Song, Xin-Feng, Li   +2 more
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Myxomatous degeneration of the lumbar intervertebral disc

Neurosurgery, 1985
Abstract Sixteen patients were operated on for lumbar pain and pain radiating into the sciatic nerve distribution. In all 16, when the anulus fibrosus was incised, soft, gray disc material extruded under pressure like toothpaste being squeezed from a tube.
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Genetic aspects of intervertebral disc degeneration

Reviews in the Neurosciences, 2015
Abstract Intervertebral disc degeneration (IVDD) is one of the common causes of low back pain. Similar to many other multifactorial diseases, it is affected by environmental and genetic factors. Although not completely understood, genetic factors include a wide spectrum of variations, such as single nucleotide polymorphisms, which could ...
Sara, Hanaei, Sina, Abdollahzade, Alireza, Khoshnevisan, Christopher K, Kepler, Nima, Rezaei   +4 more
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Biochemical changes in intervertebral disc degeneration

Biochimica et Biophysica Acta (BBA) - General Subjects, 1981
The distribution of the principal matrix components, collagen, proteoglycans and water, across the diameter of human normal and degenerate intervertebral discs was compared. Little difference in collagen distribution was noted between normal and degenerate tissue but water and proteoglycan content decreased with degeneration, particularly in the centre
G, Lyons, S M, Eisenstein, M B, Sweet
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Molecular basis of intervertebral disc degeneration

The Spine Journal, 2004
This review will acquaint the reader with normal development, structure, and function of the intervertebral disc. The disc is composed of the vertebral endplate, nucleus pulposus, and annulus fibrosus. These three functional components all serve important purposes for health and function of the disc. Nutrition and biomechanics are also discussed.
Matthew H, Walker, D Greg, Anderson
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Molecular Basis of Intervertebral Disc Degeneration

2012
Intervertebral disc (IVD) degeneration is a disease of the discs connecting adjoining vertebrae in which structural damage leads to degeneration of the disc and surrounding area. Degeneration of the disc is considered to be a normal process of aging, but can accelerate faster than expected or be precipitated by other factors.
Dipika, Gopal, Allen L, Ho, Amol, Shah, John H, Chi   +3 more
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Mechanobiology in intervertebral disc degeneration and regeneration

The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2005
The intervertebral disc is an avascular, pliant, composite structure that separates spinal vertebrae and, in health, serves to support compression and facilitate movement. Its morphological organization is directed by fluid pressure and consists of a central swelling gel (nucleus), surrounded peripherally by a constraining ligament (annulus fibrosus ...
J C, Lotz, A, Staples, A, Walsh, A H, Hsieh   +3 more
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