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Mechanical Initiation of Intervertebral Disc Degeneration
Spine, 2000Mechanical testing of cadaveric lumbar motion segments.To test the hypothesis that minor damage to a vertebral body can lead to progressive disruption of the adjacent intervertebral disc.Disc degeneration involves gross structural disruption as well as cell-mediated changes in matrix composition, but there is little evidence concerning which comes ...
M A, Adams +4 more
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The molecular basis of intervertebral disc degeneration
The Spine Journal, 2013Intervertebral disc (IVD) degeneration remains a clinically important condition for which treatment is costly and relatively ineffective. The molecular basis of degenerative disc disease has been an intense focus of research recently, which has greatly increased our understanding of the biology underlying this process.To review the current ...
Christopher K, Kepler +4 more
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Aging and Degeneration of the Human Intervertebral Disc
Spine, 1995Human intervertebral discs undergo age-related degenerative changes that contribute to some of the most common causes of impairment and disability for middle aged and older persons: spine stiffness, neck pain, and back pain. Potential causes of the age-related degeneration of intervertebral discs include declining nutrition, loss of viable cells, cell ...
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Cell death in intervertebral disc degeneration
Apoptosis, 2013Degeneration of intervertebral disc (IVD) is mainly a chronic process of excessive destruction of the extracellular matrix (ECM), and also is thought to be the primary cause of low back pain. Presently, however, the underlying mechanism of IVD degeneration is still not elucidated.
Fan, Ding, Zeng-wu, Shao, Li-ming, Xiong
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Aging and Degeneration in the Lumbar Intervertebral Disc
Orthopedic Clinics of North America, 19771. The maintenance of the nucleus pulposus matrix in the adult human disc is dependent on the functional integrity of the cartilage end plate cells. 2. Cartilage end plate senescence is followed by compensatory cartilaginous metaplasia of annulus fibrosus cells. 3.
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Magnetic Resonance Classification of Lumbar Intervertebral Disc Degeneration
Spine, 2001C. Pfirrmann +4 more
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Nanobacteria and intervertebral disc degeneration
Medical Hypotheses, 2005Hossein, Eskandary +2 more
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Intervertebral disc cell biosynthesis in the degenerate and non-degenerate intervertebral disc
2015Conference Theme: Recent Advances and Challenges in Understanding Cartilage ...
Kudelko, MA +5 more
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