Results 301 to 310 of about 81,428 (351)

Targeting nucleus pulposus cell death in the treatment of intervertebral disc degeneration. [PDF]

JOR Spine
Sun H, Guo J, Xiong Z, Zhuang Y, Ning X, Liu M.   +5 more
europepmc   +1 more source

Bone mesenchymal stem cells based on matric hydrogels attenuate intervertebral disc degeneration by suppressing oxidative stress-induced ferroptosis. [PDF]

Sci Rep
Fu S, Lv R, Wang L, Wang Z, Wang F, Gao H, Zhao W, Huang X, Li X, Wang Y.   +9 more
europepmc   +1 more source

The JNK signaling pathway in intervertebral disc degeneration. [PDF]

Front Cell Dev Biol
Liu G, Gao L, Wang Y, Xie X, Gao X, Wu X.   +5 more
europepmc   +1 more source

Analysis of Key Differential Metabolites in Intervertebral Disc Degeneration Based on Untargeted Metabolomics. [PDF]

JOR Spine
Zhou D, Zhang X, Lv J, Mei Y, Luo Y, Li F, Liu Z.   +6 more
europepmc   +1 more source

Piezo1 promotes intervertebral disc degeneration through the Ca²⁺/F-actin/Yap signaling axis. [PDF]

Mol Med
Peng F, Sun M, Jing X, Chen F, Cao T, Li Z, Li T.   +6 more
europepmc   +1 more source

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Fundamentals of Intervertebral Disc Degeneration

World Neurosurgery, 2022
Lumbar disc degeneration is one of the leading causes of chronic low back pain. The degenerative cascade is often initiated by an imbalance between catabolic and anabolic processes in the intervertebral discs. As a consequence of extracellular matrix degradation, neoinnervation and neovascularization take place.
Sertac Kirnaz, Charisse Capadona, Taylor Wong, Jacob L. Goldberg, Branden Medary, Fabian Sommer, Lynn B. McGrath, Roger Härtl   +7 more
openaire   +2 more sources

Genetics of Intervertebral Disc Degeneration

Current Osteoporosis Reports, 2023
Intervertebral disc degeneration is a contributor to chronic back pain. While a part of the natural aging process, early or rapid intervertebral disc degeneration is highly heritable. In this review, we summarize recent progress towards unraveling the genetics associated with this degenerative process.Use of large cohorts of patient data to conduct ...
David C. Ou-Yang, Christopher J. Kleck, Cheryl L. Ackert-Bicknell   +2 more
openaire   +2 more sources

Intervertebral disc degeneration

European Spine Journal, 1993
Disc degeneration in the human spine is a complex phenomenon characterised by biochemical change in the nucleus pulposus and inner annulus and the formation of clefts and fissures radiating from the central area of the disc towards the periphery. In addition, and probably independent of these phenomena, discrete defects in the outer annular attachement
Barrie Vernon-Roberts, Robert D. Fraser, O. L. Osti   +2 more
openaire   +3 more sources

Smoking and intervertebral disc degeneration

Medical Hypotheses, 2001
Cigarette smokers have an increased risk of low back pain which may be caused by disc degeneration and spinal instability, for example. Ischemia, apoptosis, faulty synthesis of disc macromolecules, and an imbalance between disc matrix proteinases and their inhibitors may be involved in the pathogenesis of disc degeneration. Along with degeneration, the
R.R. Fogelholm, A.V.Alho
openaire   +3 more sources

Genetics of the Degenerated Intervertebral Disc

World Neurosurgery, 2012
Given the genetic and proteomic advances of the past decade, understanding of the molecular etiopathogenesis of several complex diseases is increasing. Intervertebral disc disease (IVDD) is no different from other complex diseases where both environmental and genetic constituents are considered causes.
Nikolay L. Martirosyan, Guy G. Broc, Nicholas Theodore, Samuel Kalb, M. Yashar S. Kalani   +4 more
openaire   +3 more sources