Results 161 to 170 of about 23,944 (304)

tsRNA-04002 alleviates intervertebral disk degeneration by targeting PRKCA to inhibit apoptosis of nucleus pulposus cells. [PDF]

J Orthop Surg Res, 2023
Pan J, Liu Z, Shen B, Xu J, Dai G, Xu W, Wang J, Li L, Cheng L.   +8 more
europepmc   +1 more source

Evaluation of intervertebral disk degeneration in chondrodystrophic and nonchondrodystrophic dogs by use of Pfirrmann grading of images obtained with low-field magnetic resonance imaging [PDF]

, 2011
Niklas Bergknut, Edoardo Auriemma, Saffiera Wijsman, George Voorhout, Ragnvi Hagman, Anne‐Sofie Lagerstedt, Herman A. W. Hazewinkel, Björn P. Meij   +7 more
openalex   +1 more source

Enzymatic Behavior of Condoliase in Porcine Nucleus Pulposus: Ex Vivo and In Vitro Assessment

JOR SPINE, Volume 8, Issue 4, December 2025.
Condoliase digested chondroitin sulfate locally, and did not digest the collagen fibers that form the supportive architecture of the nucleus pulposus. ABSTRACT Background Condoliase is a treatment for lumbar disc herniation. This enzyme exerts its medicinal effects by digesting chondroitin sulfate (CS), which is abundant in the nucleus pulposus ...
Ippei Watanabe, Ko Takeda, Taiichi Shirogane   +2 more
wiley   +1 more source

Chrysin attenuates intervertebral disk degeneration via dual inhibition of matrix metalloproteinases and senescence: integrated network pharmacology, molecular docking, and experimental validation. [PDF]

Front Med (Lausanne)
Pang Z, Hu J, Zhao C, Li X, Zhu Y, Li X, Wang Y, Zhou Q, Li P.   +8 more
europepmc   +1 more source

Hsa_circ_0001946 Ameliorates Mechanical Stress-induced Intervertebral Disk Degeneration Via Targeting miR-432-5p and SOX9. [PDF]

Spine (Phila Pa 1976), 2023
Xiang Q, Wang J, Cheng Z, Zhao K, Gan W, Chen Y, Zhang Y.   +6 more
europepmc   +1 more source

Canonical Wnt signaling in the notochordal cell is upregulated in early intervertebral disk degeneration [PDF]

, 2011
Lucas A. Smolders, Björn P. Meij, Frank M. Riemers, Ruud Licht, Richard Wubbolts, Douwe van den Heuvel, Guy C. M. Grinwis, J.C.M. Vernooij, Herman A.W. Hazewinkel, Louis C. Penning, Marianna A. Tryfonidou   +10 more
openalex   +1 more source

Circadian Rhythm: Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 6, Issue 11, November 2025.
This review offers a comprehensive overview of the mechanisms by which circadian rhythms modulate tissue homeostasis, alongside the associations between circadian disturbances and circadian rhythm‐related diseases. Furthermore, we offer insights into circadian rhythm‐regulating therapies, which may contribute to the development of novel strategies for ...
Kangkang Zha, Bobin Mi, Yuan Xiong, Shuyan Wu, Li Lu, Shengming Zhang, Xuan Lu, Hei Chung Mak, Jianping Huang, Adriana C. Panayi, Samuel Knoedler, Lili Chen, Guohui Liu, Sien Lin   +13 more
wiley   +1 more source

Silk fibroin-collagen hydrogel loaded with IGF1-CESCs attenuates intervertebral disk degeneration by accelerating annulus fibrosus healing in rats. [PDF]

Front Pharmacol
Tian Z, Shen Z, Chen H, Zhao P.
europepmc   +1 more source

Quantitative ²³ Na-MRI of the intervertebral disk at 3 T. [PDF]

NMR Biomed, 2022
Çavuşoğlu M, Pazahr S, Ciritsis AP, Rossi C.   +3 more
europepmc   +1 more source

Morphology of the Cartilaginous Endplates in Human Intervertebral Disks with Ultrashort Echo Time MR Imaging [PDF]

, 2012
Won C. Bae, Sheronda Statum, Zhao Zhang, Tomonori Yamaguchi, Tanya Wolfson, Anthony Gamst, Jiang Du, Graeme M. Bydder, Koichi Masuda, Christine B. Chung   +9 more
openalex   +1 more source