Results 201 to 210 of about 23,944 (304)

Gene-Silencing Therapeutic Approaches Targeting PI3K/Akt/mTOR Signaling in Degenerative Intervertebral Disk Cells: An In Vitro Comparative Study Between RNA Interference and CRISPR-Cas9. [PDF]

Cells
Ryu M, Yurube T, Takeoka Y, Kanda Y, Tsujimoto T, Miyazaki K, Ohnishi H, Matsuo T, Kumagai N, Kuroshima K, Hiranaka Y, Kuroda R, Kakutani K.   +12 more
europepmc   +1 more source

Refinement of Elastic, Poroelastic, and Osmotic Tissue Properties of Intervertebral Disks to Analyze Behavior in Compression

, 2010
Ian A. F. Stokes, Jeffrey P. Laible, Mack Gardner‐Morse, John J. Costi, James C. Iatridis   +4 more
openalex   +2 more sources

Novel Molecular Phenotype of Notochordal-Like Cells in Nucleus Pulposus of Human Intervertebral Disk [PDF]

, 2012
X. Tang, L. Jing, L. Setton, W. Richardson, R. Fitch, R. Isaacs, C. Brown, J. Chen   +7 more
openalex   +1 more source

PIEZO1‐GPX4 Axis Mediates Mechanical Stress‐Induced Vertebral Growth Plate Dysplasia via Ferroptosis Activation

Advanced Science, Volume 12, Issue 39, October 20, 2025.
Mechanical stress activates PIEZO1 in vertebral growth plate chondrocytes, triggering ferroptosis through direct binding and inhibition of GPX4. This axis promotes lipid peroxidation and pathological ossification, accelerating spinal deformities. Clinical and genetic evidence (Piezo1‐cKO) confirms its role in scoliosis progression.
Fei Chen, Fushuai Peng, Shuqing Chen, Yukun Du, Jianyi Li, Yuanyuan Fan, Zichen Cui, Guanghui Gu, Han Zhang, Zhensong Jiang, Guodong Wang, Xingzhi Jing, Jun Dong, Tao Li, Yongming Xi   +14 more
wiley   +1 more source

Circular RNAs in compression-induced intervertebral disk degeneration

EBioMedicine, 2020
Ximiao Chen, Mingbao Gu, Xiaolei Zhang
doaj   +1 more source

The Effect of Intervertech 1 on Proteoglycan and Collagen Expression in Human Intervertebral Disk Cells [PDF]

, 2012
F. Mwale, H. Wang, P. Madiraju, R. Gawri, A. Almaawi, L. Haglund, J. Antoniou   +6 more
openalex   +1 more source

Deciphering the Acetabular Labrum's Cellular Atlas: MDK Inhibition as a Novel Therapeutic Method for Developmental Dysplasia of the Hip

Advanced Science, Volume 12, Issue 37, October 6, 2025.
This study explores developmental dysplasia of the hip (DDH) by analyzing acetabular labrum abnormalities using single‐cell and spatial transcriptomics. Aberrant fibrocartilage stem cell proliferation is linked to DDH progression. Targeting the MK signaling pathway with a specific inhibitor effectively alleviates early DDH abnormalities, offering ...
Runze Yang, Huiling Liu, Minghao Ge, Dingyuan Zhang, Tianhao Xu, Lei Zhang, Yanlin Zhu, Shun Li, Jian Li, Xin Ma, Weili Fu   +10 more
wiley   +1 more source

Causal effects of skin microbiota on intervertebral disk degeneration, low back pain and sciatica: a two-sample Mendelian randomization study. [PDF]

J Orthop Surg Res
Jia Y, Chen H, Huang S, Huo Z, Xu B.
europepmc   +1 more source

Open Challenges and Opportunities in Piezoelectricity for Tissue Regeneration

Advanced Science, Volume 12, Issue 38, October 13, 2025.
This review provides an intriguing review of the recent advancements, challenges, and future perspectives regarding the application of piezoelectric scaffolds in tissue regeneration. The detailed exposition is anticipated to propel the advancement of personalized and intelligent piezoelectric implants, thereby fostering significant progress in this ...
Xiaoling Deng, Yu Zhuang, Jinjie Cui, Liyun Wang, Huilu Zhan, Xudong Wang, Kaili Lin, Changyong Yuan   +7 more
wiley   +1 more source

Clinical features of early recurrence of type I thoracolumbar intervertebral disk herniation in Miniature Dachshunds. [PDF]

J Vet Med Sci
Sakaguchi Y, Nishida H, Tanaka H, Kitamura M, Izawa T, Nakayama M.   +5 more
europepmc   +1 more source