Results 211 to 220 of about 23,944 (304)

Exosomes in Intervertebral Disc Regeneration: Roles, Opportunities, and Challenges

Advanced NanoBiomed Research, Volume 5, Issue 10, October 2025.
Factors of Intervertebral Disc Degeneration Extracellular Matrix (ECM) Exosomes and Intervertebral Disc Degeneration (IVDD) Exosome‐Mediated Therapy for IVDD of Different Cell Sources Application of Engineered Exosomes in IVDD Clinical Application of Exosomes in IVDD Treatment Conclusion and Future Perspectives. Intervertebral disc degeneration (IVDD),
Xianglong Zhou, Tianyi Xia, Jiheng Xiao, Jianhui Xiang, Hanhong Fang, Haoran Zhou, Yiqiang Hu, Liming Xiong   +7 more
wiley   +1 more source

Intervertebral Disk Degeneration and Bone Mineral Density: A Bidirectional Mendelian Randomization Study. [PDF]

Calcif Tissue Int
Zhao J, Wang J, Xu H, Hu W, Shi F, Fan Z, Zhou C, Mu H.   +7 more
europepmc   +1 more source

Cervical Discitis in a 20‐Year‐Old Female: A Case Report

Clinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT Spondylodiscitis, particularly cervical discitis, is a rare infectious condition that can result in severe complications if untreated. This report highlights the rarity of this condition in our female patient's age group and its occurrence in the cervical region in the absence of underlying medical issues. Our article presents a unique case of
Saja Karaja, Ahed Assaf, Shafiq Alassaf, Elias Tannous, Hazem Arab, Mulham Alkassem, Amer Al Tawekji   +6 more
wiley   +1 more source

Expanding the Spectrum: A Rare Case of Morquio Syndrome With Bronchial Asthma and Seizure Disorder

Clinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT This case highlights a rare co‐existence of Morquio syndrome with bronchial asthma and myoclonic seizures, expanding the known clinical spectrum. It emphasizes the need for comprehensive, multidisciplinary management to address multisystem involvement and describes the challenges of treatment in resource‐limited settings where advanced ...
Bijay Bastola, Sweekar Dahal, Ramesh Raj Acharya, Manish Sah, Pratisma Wagle   +4 more
wiley   +1 more source

First Report of Intervertebral Disc Calcification in a Black Child in Sub‐Saharan Africa

Clinical Case Reports, Volume 13, Issue 10, October 2025.
Standard X‐ray of the cervical spine from the front and in profile. Blurred appearance of the C2–C3 and C3–C4 vertebral endplates and calcification (orange arrow) in the intervertebral disc of C2–C3. ABSTRACT We report an intervertebral disc calcification in a Black African child who had consulted us for neck pain. The diagnosis of C2–C3 intervertebral
Yamyelle Enselme Zongo, Ismael Ayouba Tinni, Hamiidah Hunsu‐Horhon Guingani, Yannick Laurent Tchenadoyo Bayala, Aboubakar Ouedraogo, Fulgence Kabore, Wendlassida Stéphanie Joelle Zabsonré/Tiendrebeogo, Dieu‐Donné Ouedraogo   +7 more
wiley   +1 more source

HNF1β Gene Mutation Leading to a MODY5 With Renal Dysplasia: A Case Report

Clinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT This case report describes a 20‐year‐old female MODY5 patient. Genetic testing revealed a heterozygous missense mutation c.452C>G (p.R151G) in HNF1β, identical to the mutation carried by her diabetic mother. This case underscores the importance of genetic testing in young‐onset diabetes with renal anomalies, facilitating personalized care and ...
Xingfa Han, Xueting Qiu, Rong Jiang, Nian Wang, Zheng Li, Zhimin Ma   +5 more
wiley   +1 more source

The Role of Trabecular, Ligamentous-Intervertebral Disk and Facet Joints Systems: A Finite Element Analysis in the L4-S1 Vertebrae. [PDF]

Global Spine J
Guerrero-Vargas JA, Sanchez-Quinones P, Pinzón BF, Vélez-Muriel M, Madriñan-Navia H, Laverde-Frade L.   +5 more
europepmc   +1 more source

A Computational Multiscale Framework for Bone Remodeling: Coupling Apparent Density Evolution and Microscale Shape Optimization

International Journal for Numerical Methods in Biomedical Engineering, Volume 41, Issue 10, October 2025.
This study introduces a multiscale patient‐specific framework that couples mechano‐biological bone remodeling at the macroscale with microscale shape optimization. The framework is validated through literature case studies and demonstrates how remodeling influences vertebral fracture behavior.
Balavignesh Vemparala, Mingshi Ji, Prasath Mageswaran, Gregory G. Knapik, Khaled Dibs, Dukagjin M. Blakaj, Eric C. Bourekas, Ehud Mendel, William S. Marras, Soheil Soghrati   +9 more
wiley   +1 more source

Changes in the composition of the fecal metabolome and gut microbiota contribute to intervertebral disk degeneration in a rabbit model. [PDF]

J Orthop Surg Res
Cheng S, Yu J, Cui M, Su H, Cao Y.
europepmc   +1 more source

Exploring the 3D Bioprinting Landscape in the Delivery of Active Pharmaceutical Compounds for Therapeutic and Regenerative Medicine Applications

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 113, Issue 10, October 2025.
Three‐dimensional (3D) bioprinting is revolutionizing drug delivery and regenerative medicine by enabling personalized, controlled‐release therapeutic systems. This review explores advancements in biocompatible bioinks, nanomedicines, and 3D‐printed drug delivery constructs, including scaffolds, implants, and bioactive hydrogels.
Khonzisizwe Somandi, Yahya E. Choonara
wiley   +1 more source