Results 251 to 260 of about 68,127 (346)

Macrophage Changes and High‐Throughput Sequencing in Aging Mouse Intervertebral Disks

JOR SPINE, Volume 8, Issue 2, June 2025.
We aimed to evaluate caudal IVD specimens from adult and older mice to study M0, M1, and M2 macrophage polarization and their aging‐related secretory phenotypes. Additionally, we aimed to assess macrophage polarization in aged disks, along with the differential expression of genes related to aging, and the hub genes involved in aging.
Wei Wang, Cheng Jiang, Jiong‐Hui Chen, Yong‐Long Chen, Zhen‐Wu Zhang, Zhi‐Chao Yang, Jun Li, Xiao‐Chuan Li   +7 more
wiley   +1 more source

Characterization of risk factors for early ambulation in paraplegic dogs with absent pain perception undergoing decompressive surgery for thoracolumbar intervertebral disk extrusions. [PDF]

Front Vet Sci
Gomes SA, Alvites RD, Lopes B, Coelho A, Targett M, Ribeiro J, Gouveia D, Martins Â, Varejão ASP, Maurício AC, Luís AL.   +10 more
europepmc   +1 more source

A Model for Intervertebral Disk Shape Variation in a Population Including the Effect of Degeneration [PDF]

, 2012
Edward J. Vresilovic, John Peloquin, Jonathon H. Yoder, Nathan T. Jacobs, S. Moon, Alexander C. Wright, Dawn M. Elliott   +6 more
openalex   +1 more source

Presumptive acute non-compressive nucleus pulposus extrusion in 11 cats: clinical features, diagnostic imaging findings, treatment and outcome [PDF]

, 2017
De Decker, S, Taylor-Brown, F E
core   +1 more source

Phosphatidylcholine Ameliorates Palmitic Acid‐Induced Lipotoxicity by Facilitating Endoplasmic Reticulum and Mitochondria Contacts in Intervertebral Disc Degeneration

JOR SPINE, Volume 8, Issue 2, June 2025.
The abnormal lipotoxic condition in nucleus pulposus (NP) cells from advanced‐stage intervertebral disc degeneration (IDD) was identified through untargeted LC/MS metabolomics and magnetic resonance spectroscopy. The palmitic acid accumulation resulted in endoplasmic reticulum stress, mitochondrial damage, lipid droplet accumulation, and senescence of ...
Shuangshuang Tu, Yijun Dong, Chuanfu Li, Mingxin Jiang, Liqun Duan, Wenzhi Zhang, Xi Chen   +6 more
wiley   +1 more source

Gene-Silencing Therapeutic Approaches Targeting PI3K/Akt/mTOR Signaling in Degenerative Intervertebral Disk Cells: An In Vitro Comparative Study Between RNA Interference and CRISPR-Cas9. [PDF]

Cells
Ryu M, Yurube T, Takeoka Y, Kanda Y, Tsujimoto T, Miyazaki K, Ohnishi H, Matsuo T, Kumagai N, Kuroshima K, Hiranaka Y, Kuroda R, Kakutani K.   +12 more
europepmc   +1 more source

Acupuncture in the Treatment of Sequestered Intervertebral Disk Herniation. [PDF]

Med Acupunct, 2021
Buevich V, Buevich M, Buevich N.
europepmc   +1 more source

Evidence for a Causal Association Between Human Cytomegalovirus Infection and Chronic Back Pain: A One‐Sample Mendelian Randomization Study

JOR SPINE, Volume 8, Issue 2, June 2025.
ABSTRACT Background Chronic back pain (CBP) is a major cause of disability globally. While its etiology is multifactorial, specific contributing genetic and environmental factors remain to be discovered. Paraspinal muscle fat has been shown in human and preclinical studies to be related to CBP. One potential risk factor is infection by cytomegalovirus (
Maryam Kazemi Naeini, Maxim B. Freidin, Isabelle Granville Smith, Stephen Ward, Frances M. K. Williams   +4 more
wiley   +1 more source

Nrf2 activation by pyrroloquinoline quinone inhibits natural aging-related intervertebral disk degeneration in mice. [PDF]

Aging Cell
Xue Q, Li J, Qin R, Li M, Li Y, Zhang J, Wang R, Goltzman D, Miao D, Yang R.   +9 more
europepmc   +1 more source

434 Study on Noninvasive Estimate System for Intervertebral Disk Load

, 2009
Kyoko SHIBATA, Yoshio INOUE, Shinji Yamamoto, Hisashi DOIHARA, Yoshitaka Iwata, Takahiro Kiyooka   +5 more
openalex   +2 more sources