Results 281 to 290 of about 68,127 (346)

Relationship Between Lumbar Multifidus Morphometry and Pain/Disability in Individuals With Chronic Nonspecific Low Back Pain After Considering Demographics, Fear‐Avoidance Beliefs, Insomnia, and Spinal Degenerative Changes

JOR SPINE, Volume 8, Issue 2, June 2025.
We examined the associations between fatty infiltration of the lumbar multifidus muscle and clinical outcomes (pain intensity and disability) in people with chronic nonspecific low back pain after controlling for various confounders like demographics, fear‐avoidance beliefs, insomnia, and spinal degenerative phenotypes.
Sabina M. Pinto, Jason P. Y. Cheung, Dino Samartzis, Jaro Karppinen, Yong‐Ping Zheng, Marco Y. C. Pang, Maryse Fortin, Arnold Y. L. Wong   +7 more
wiley   +1 more source

The Role of Sex Hormones in Cartilaginous Tissues: A Scoping Review

JOR SPINE, Volume 8, Issue 2, June 2025.
The role of sex hormones within cartilaginous tissues remains poorly understood. To address this, we assembled and summarized the available literature regarding the effects of sex hormones in the intervertebral disc, temporomandibular joint, and articular cartilage.
Jeffrey L. Hutchinson, Amalie J. Hutchinson, Joy Feng, Cheryle A. Séguin   +3 more
wiley   +1 more source

Changes in the composition of the fecal metabolome and gut microbiota contribute to intervertebral disk degeneration in a rabbit model. [PDF]

J Orthop Surg Res
Cheng S, Yu J, Cui M, Su H, Cao Y.
europepmc   +1 more source

An Extracellular Matrix Hydrogel Restores Disc Volume and Alleviates Axial Hypersensitivity in a Rat Model of Disc‐Associated Pain

JOR SPINE, Volume 8, Issue 2, June 2025.
Degenerated painful discs present with mechanical instability, inflammation, and nerve sprouting, however, patients treated with spinal stabilizing procedures often report pain alleviation indicating spinal mechanics, could be causative in the production of pain.
David J. Lillyman, Evie C. Reddick, Kayla E. Ney, Sydney M. Caparaso, Rebecca A. Wachs   +4 more
wiley   +1 more source

Apoptosis in Temporomandibular Joint Disc with Internal Derangement Involves Mitochondrial-dependent Pathways. An \u3cem\u3ein vivo\u3c/em\u3e Study [PDF]

, 2013
Almeida, Luis Eduardo, Bartoloni, Giovani, Caltabiano, Rosario, Leonardi, Rosalia, Loreto, Carla, Musumeci, Giuseppe, Rusu, Mugurel Constantin   +6 more
core   +1 more source

In Vivo Measurements Reveal Increased Nucleus Pulposus Lactate and Oxygen Concentrations in a Goat Model of Intervertebral Disc Degeneration

JOR SPINE, Volume 8, Issue 2, June 2025.
Although precise pathophysiological mechanisms remain elusive, perturbations in nutrition that adversely impact the cellular microenvironment of the central nucleus pulposus (NP) are considered key contributors to disc degeneration. In this study, we adapted brain tissue oxygen probes and microdialysis catheters for in situ determination of NP tissue ...
Karthikeyan Rajagopal, Thomas P. Schaer, Kyle D. Meadows, Madeline Boyes, Rachel Hilliard, John C. O'Donnell, George R. Dodge, Dmitriy Petrov, Dawn M. Elliott, Robert L. Mauck, Lachlan J. Smith, Neil R. Malhotra   +11 more
wiley   +1 more source

In Vitro Validation of Pulsed Electromagnetic Field (PEMF) as an Effective Countermeasure Against Inflammatory‐Mediated Intervertebral Disc Degeneration

JOR SPINE, Volume 8, Issue 2, June 2025.
ABSTRACT Background Intervertebral disc (IVD) degeneration (IDD) is the main contributor to chronic low back pain (LBP), the leading cause of disability worldwide, with a significant impact on the quality of life and health of common people. The etiology of IDD is still unclear, but it has been largely demonstrated the crucial role of inflammation and ...
Laura Guarnaccia, Laura Begani, Silvana Pileggi, Mauro Pluderi, Stefano Borsa, Claudia Fanizzi, Massimiliano Domenico Rizzaro, Giorgio Fiore, Laura Fontana, Rolando Campanella, Chiara Cordiglieri, Chiara Gaudino, Giovanni A. Alotta, Monica Miozzo, Emanuele Garzia, Emanuela Barilla, Lorenzo Fassina, Laura Riboni, Marco Locatelli, Giovanni Marfia, Stefania E. Navone   +20 more
wiley   +1 more source

Neochlorogenic Acid Combined with Bone Marrow Mesenchymal Stem Cells Encapsulated into GelMA Hydrogel for Transplantation to Repair Intervertebral Disk Degeneration. [PDF]

Biomacromolecules
Fang Y, Hu J, Zou Y, Wang Z, Ye Y, Zhang C.   +5 more
europepmc   +1 more source

Causal Relationship Between Gut Microbiota, Blood Metabolites, and Intervertebral Disc Degeneration: A Two‐Step, Two‐Sample Bidirectional Mendelian Randomization Study

JOR SPINE, Volume 8, Issue 2, June 2025.
We have identified several specific gut microbiota that may have an effect on intervertebral disc degeneration, and have found possible blood metabolites that mediate the effects of the gut microbiota on intervertebral disc degeneration. This study provides new insights into the mechanisms by which gut microbes are involved in the development of ...
Yi‐Ping Zheng, Dong‐Lin Yang, Lu‐Yang Wang, Xi‐Zhong Zhu, Xing‐Chen Li, Jin‐Hong Miao, Yu‐Sheng Xu   +6 more
wiley   +1 more source

Crosstalk Between Ferroptosis and Cuproptosis in Intervertebral Disc Degeneration: Mechanisms, Therapeutic Targets, and Future Directions

JOR SPINE, Volume 8, Issue 2, June 2025.
GSH, oxidative stress, TCA cycle, autophagy, and copper are the intersection targets of ferroptosis and cuproptosis in IVDD. ABSTRACT Background Intervertebral disc degeneration (IVDD) is a prevalent degenerative disease, with low back pain as its primary clinical symptom, imposing significant burdens on individuals and society.
Zhongpan Li, Liangwei Wang, Xiaojun Wu, Rui Huang, Yi Yuan   +4 more
wiley   +1 more source