Results 51 to 60 of about 23,944 (304)

Raloxifene retards the progression of adjacent segmental intervertebral disc degeneration by inhibiting apoptosis of nucleus pulposus in ovariectomized rats

Journal of Orthopaedic Surgery and Research, 2021
Background Adjacent segmental intervertebral disk degeneration (ASDD) is a major complication secondary to lumbar fusion. Although ASSD pathogenesis remains unclear, the primary cause of intervertebral disk degeneration (IVDD) development is apoptosis of
Qi Sun, Xin-Yu Nan, Fa-Ming Tian, Fang Liu, Shao-Hua Ping, Zhuang Zhou, Liu Zhang   +6 more
doaj   +1 more source

Extracellular Vesicle‐Based mRNA Therapeutics and Vaccines

Exploration, EarlyView.
This review provides a comprehensive analysis of recent advancements in extracellular vesicle (EV)‐based messenger RNA (mRNA) applications for therapeutics and vaccines. It systematically outlines strategies for mRNA encapsulation within EVs and elucidates the challenges associated with this technology, offering insights into future research directions
Qi Li, Haonan Xing, Abid Naeem, Kaiyue Zhang, Aiping Zheng, Yuanyu Huang, Mei Lu   +6 more
wiley   +1 more source

Kaempferol Alleviates Acrolein‐Induced Lung Injury In Vitro and In Vivo by Binding to Peli2 and Disrupting the Peli2‐NLRP3 Interaction

Food Frontiers, EarlyView.
Abstract Acrolein (ACR) is a highly toxic agent that induces lung inflammation and causes acute lung injury (ALI). However, effective treatments for ACR‐induced ALI are currently lacking. We investigated the protective effects of kaempferol (Kae) against ACR‐induced ALI using in vitro (HBE and BEAS‐2B cells) and in vivo murine models (male C57BL/6 mice)
Juanjuan Ma, Zhao Yin, Jie Zheng, Xingyou Mo, Shaoji Li, Hua Liu, Shiyi Ou   +6 more
wiley   +1 more source

A Phase 1 Study of the Pharmacokinetics, Safety, and Tolerability of Posdinemab (JNJ‐63733657) in Healthy Chinese Adults

The Journal of Clinical Pharmacology, EarlyView.
Abstract Posdinemab, a humanized immunoglobulin G1/κ monoclonal antibody, binds with high affinity to phosphorylated tau protein which is associated with Alzheimer's disease (AD) pathophysiology. Posdinemab reduced tau seeding in murine models and was well tolerated in Phase‐1 clinical studies.
Fangfang Wang, Juanfang Liu, Daisy Bai, Lingjue Li, Maggie Fedgchin, David Henley, Haiyan Li, Fan Zhang   +7 more
wiley   +1 more source

Characterizing Microstructural and Mechanical Properties of Dancer Achilles Tendon Using Ultrashort Echo Time MRI and Shear Wave Elastography Ultrasound

Journal of Orthopaedic Research, EarlyView.
ABSTRACT Previous observations of multi‐echo ultrashort echo time (UTE) magnetic resonance imaging (MRI) decay data from the Achilles tendon (AT) report an off‐resonance non‐water signal associated with non‐collagenous extracellular matrix (ECM) constituents.
Anna M. Horner, Felix M. Gonzalez, Courtney N. Gleason, Amanda Blackmon, Emma Faulkner, Damian Dyckman, Monica B. Umpierrez, Philip K.‐W. Wong, Vahid Khalilzad Sharghi, Pan Su, David A. Reiter   +10 more
wiley   +1 more source

Therapeutic Window of Laser Dosimetry for the Treatment of Knee Osteoarthritis

Lasers in Surgery and Medicine, EarlyView.
ABSTRACT Objectives We propose a non‐destructive laser method that uses controlled thermomechanical action to treat degenerative cartilage changes. The technique aims to reduce pain, offers a minimally invasive option for early‐ to mid‐stage degeneration, and lessens the need for joint replacement.
Yulia Alexandrovskaya, Felix Feldchtein, Andreas Glatz, Anatoly Shekhter, Elizaveta Kon, Valerii Vinokur, Emil Sobol   +6 more
wiley   +1 more source

Novel Antioxidant and Antibacterial Injectable Hydrogels Incorporating Clove Oil‐Loaded Mesoporous Bioactive Glass Nanoparticles: A Promising Strategy for Enhanced Bone Regeneration

Macromolecular Bioscience, EarlyView.
A novel injectable hydrogel composed of alginate–gelatin–xanthan gum incorporating clove oil (CLV)‐loaded mesoporous bioactive glass nanoparticles is developed. The system demonstrates enhanced antioxidant and antibacterial activity, increased Young's modulus, and good injectability.
Andrada‐Ioana Damian‐Buda, Markus Lorke, Aldo R. Boccaccini, Irem Unalan   +3 more
wiley   +1 more source

Preclinical development of a microRNA-based therapy for intervertebral disc degeneration

Nature Communications, 2018
Intervertebral disk degeneration (IDD) is characterized by changes in the nucleus pulposus (NP) extra cellular matrix that compromise disk structural integrity.
Ming-liang Ji, Hua Jiang, Xue-jun Zhang, Pei-liang Shi, Chao Li, Hao Wu, Xiao-tao Wu, Yun-tao Wang, Chen Wang, Jun Lu   +9 more
doaj   +1 more source

Biomechanics of the Lumbar Facet Joint

Spine Surgery and Related Research, 2020
Zygapophyseal, or facet, joints are complicated biomechanical structures in the spine, with a complex three-dimensional (3D) anatomy, variable mechanical functions in different spinal movements, and effects on the overall spine mechanical behavior.
Nozomu Inoue, Alejandro A. Espinoza Orías, Kazuyuki Segami   +2 more
doaj   +1 more source

Development of a Grasshopper‐Leg‐Inspired Back‐Type Exoskeleton for the Reduction of Muscle Activation During Stoop Activities

Journal of Field Robotics, EarlyView.
ABSTRACT Farmers frequently suffer from musculoskeletal disorders, particularly lower back pain (LBP), mainly due to occupational ergonomic factors such as repetitive stooping and lifting. This study proposes using an exoskeleton to reduce LBP risk by providing external torque to the hip joints.
Dang Khanh Linh Le, Wei Chih Lin
wiley   +1 more source