Results 81 to 90 of about 68,127 (346)

WTAP Mediated m6A Modification Stabilizes PDIA3P1 and Promotes Tumor Progression Driven by Histone Lactylation in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
This study reveals a new mechanism by which PDIA3P1 regulates the progression of esophageal squamous cell carcinoma (ESCC). PDIA3P1 upregulates the expression of GLUT1 and HK2, promoting glycolysis and lactate production. Lactate upregulates the lactylation level of histone H4K8 and activates the transcription of target gene BMP7, ultimately ...
Tao Huang, Qi You, Jiawei Liu, Xuguang Shen, Dengjun Huang, Xinlu Tao, Zhijie He, Chengwei Wu, Xinran Xi, Shouqiang Yu, Feng Liu, Zhihao Wu, Wenjun Mao, Shaojin Zhu   +13 more
wiley   +1 more source

Automatic Spine Segmentation using Convolutional Neural Network via Redundant Generation of Class Labels for 3D Spine Modeling [PDF]

arXiv, 2017
There has been a significant increase from 2010 to 2016 in the number of people suffering from spine problems. The automatic image segmentation of the spine obtained from a computed tomography (CT) image is important for diagnosing spine conditions and for performing surgery with computer-assisted surgery systems.
arxiv  

Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs. [PDF]

, 2016
The main pathogenesis of intervertebral disc (IVD) herniation involves disruption of the annulus fibrosus (AF) caused by ageing or excessive mechanical stress and the resulting prolapse of the nucleus pulposus.
Asahara, Hiroshi, Ichinose, Shizuko, Inagawa, Masayo, Inui, Masafumi, Ito, Yoshiaki, Kataoka, Kensuke, Kayama, Tomohiro, Lotz, Martin K, Masuda, Koichi, Mori, Masaki, Nakamichi, Ryo, Onizuka, Naoko, Ozaki, Toshifumi, Sakai, Daisuke, Suzuki, Hidetsugu   +14 more
core   +1 more source

A mouse coccygeal intervertebral disc degeneration model with tail‐looping constructed using a suturing method

Animal Models and Experimental Medicine, EarlyView.
A novel, simple coccygeal intervertebral disc degeneration model, using a suturing method for tail‐looping, without the need for external fixation and complex surgery. The model has high reproducibility and stability and overcomes the disadvantages of the existing animal models of disc degeneration.
Wei Xie, Zemao Huang, Ziyang Huang, Deqing Luo, Zhangxin Chen, Li Xie, Lingqi Zhu, Hui Liu, Kejian Lian, Paolo Alberton, Denitsa Docheva, Dasheng Lin   +11 more
wiley   +1 more source

Molecular Imaging Agents Specific for the Annulus Fibrosus of the Intervertebral Disk

Molecular Imaging, 2010
Low back pain is a prevalent medical condition that is difficult to diagnose and treat. Current imaging methods are unable to correlate pain reliably with spinal structures, and surgical removal of painful damaged or degenerating disks is technically ...
Summer L. Gibbs-Strauss, Carrie Vooght, Kenneth M. Fish, Khaled A. Nasr, Tiberiu M. Siclovan, Nicole E. Barnhardt, Cristina A. Tan Hehir, John V. Frangioni   +7 more
doaj   +1 more source

Antioxidant Effects of Resveratrol in Intervertebral Disk

Journal of Investigative Surgery, 2022
Intervertebral disk (IVD) degeneration (IVDD) can cause various spinal degenerative diseases. Cumulative evidence has indicated that IVDD can result from inflammation, apoptosis, autophagy, biomechanical changes and other factors.
Yachong Huo, Dalong Yang, Kaitao Lai, Ji Tu, Yibo Zhu, Wenyuan Ding, Sidong Yang   +6 more
doaj   +1 more source

How many radiographs are needed to re-train a deep learning system for object detection? [PDF]

arXiv, 2022
Background: Object detection in radiograph computer vision has largely benefited from progress in deep convolutional neural networks and can, for example, annotate a radiograph with a box around a knee joint or intervertebral disc. Is deep learning capable of detect small (less than 1% of the image) in radiographs?
arxiv  

Morphology and function of pinniped necks: The long and short of it

The Anatomical Record, EarlyView.
Abstract Terrestrial vertebrates from at least 30 distinct lineages in both extinct and extant clades have returned to aquatic environments. With these transitions came numerous morphological adaptations to accommodate life in water. Relatively little attention has been paid to the cervical region when tracking this transition.
Justin Keller, Annalisa Berta, Mark Juhn, Blaire Van Valkenburgh   +3 more
wiley   +1 more source

Unveiling the complexity of cellular senescence in cancers: From mechanism to therapeutic opportunities

BMEMat, EarlyView.
This review highlights the complex roles of cellular senescence in cancer progression and suppression, discusses the mechanisms and regulatory pathways involved, and evaluates the efficacy of the “One‐Two punch” sequential treatment approach while addressing emerging challenges in this novel therapeutic strategy.
Qiuming Pan, Ye Zhu, Zhi Ye, Huayang Zhang, Junxi Wang, Guozhong Yi, Zhiyong Li, Rongyang Xu, Luyao Wang, Zhenzhen Wu, Songtao Qi, Guanglong Huang, Shanqiang Qu   +12 more
wiley   +1 more source

New Mechanics of Spinal Injury [PDF]

, 2008
The prediction and prevention of spinal injury is an important aspect of preventive health science. The spine, or vertebral column, represents a chain of 26 movable vertebral bodies, joint together by transversal viscoelastic intervertebral discs and longitudinal elastic tendons. This paper proposes a new locally-coupled loading-rate hypothesis}, which
arxiv   +1 more source