Results 251 to 260 of about 6,290,967 (378)

Okanin Suppresses the Growth of Colorectal Cancer Cells by Targeting at Peroxiredoxin 5

Advanced Science, EarlyView.
Okanin suppresses colorectal cancer growth by directly targeting PRDX5. This natural compound selectively binds peroxiredoxin 5 (PRDX5), inhibiting its activity and inducing WSB1‐mediated degradation. PRDX5 loss elevates ROS, suppresses GPX4 via SIAH2, and further triggers cell death (apoptosis and ferroptosis).
Ji Zhong Zhao, Yuan Fei Li, Fu Kang Yuan, Meng Lu Zhao, Ya Wen Han, Jia Xin Wang, Qi Yang, Han Ying Ye, Yu Cheng Lu, Shao Chin Lee   +9 more
wiley   +1 more source

Nucleotides as an Anti‐Aging Supplementation in Older Adults: A Randomized Controlled Trial (TALENTs study)

Advanced Science, EarlyView.
The TALENTs randomized controlled trial evaluates the potential of nucleotides supplementation as an anti‐aging intervention in older adults. After 19 weeks, nucleotides supplementation significantly reduces DNA methylation age, suggesting a delay in epigenetic aging, and improves insulin sensitivity without severe adverse events.
Shuyue Wang, Lixia Song, Rui Fan, Qianqian Chen, Ruisheng Fu, Mei You, Yuxiao Wu, Meng Cai, Yong Li, Meihong Xu   +9 more
wiley   +1 more source

Death and dying during the COVID-19-pandemic - A qualitative evaluation of stress factors for nursing staff. [PDF]

Palliat Care Soc Pract
Kiefer L, Bösner S, Graw JA, Volberg C.
europepmc   +1 more source

Interview with Roy Sharpe

, 1968

openalex   +1 more source

Minimally Invasive Chemical Biopsy Needle with Self‐Wettable Extraction Phase For In Vivo Tissue Sampling During Medical Procedures

Advanced Science, EarlyView.
A new tissue sampling device using an acupuncture needle with bio‐compatible extraction sorbents in the recessed section is developed. The coating material using self‐wettable particles doesn't require solvent activation after sterilization. This device is applied for the anti‐cancer drug concentration monitoring during the in vivo lung perfusion ...
Runshan Will Jiang, Wei Zhou, Marcelo Cypel, Todd L. Demmy, Gal Shafirstein, Guillermo Garza, Emily Gawrys, Joanna Bogusiewicz, Barbara Bojko, Janusz Pawliszyn   +9 more
wiley   +1 more source

Exploring the participant experience in controlled human infection model (CHIM) trials: A modified grounded theory study. [PDF]

PLoS One
Mack AG, Halperin DM, Selig BM, Condran BR, Halperin SA.   +4 more
europepmc   +1 more source

P. J. Murphy and Loyd Johnsen (1997) Life 25: Interviews with Prisoners Serving Life Sentences. Vancouver: New Star Books.

, 1969
Bobby Paul
openalex   +2 more sources

Hexokinase‐2 as a Therapeutic Target: Alleviating Herpes Simplex Keratitis Through Metabolic Reprogramming

Advanced Science, EarlyView.
Herpes Simplex Virus Type 1 (HSV‐1) infection triggers metabolic reprogramming in corneal cells, shifting from mitochondrial respiration to aerobic glycolysis with marked upregulation of Hexokinase‐2 (HK2). This study identifies HK2 as a therapeutic target: inhibiting HK2 with lonidamine significantly reduces viral replication and promotes corneal ...
Dan Jiang, Yining Sun, Xintong Yu, Ruoqi Wang, Yuting Zhang, Jinjie Yu, Shuang Xie, Yujia Cai, Yuhong Luo, Wei Chen   +9 more
wiley   +1 more source

The Impact of Preference Signaling on Interview Invitations and Match Outcomes in the 2023 to 2024 Orthopaedic Residency Cycle: A Retrospective Review. [PDF]

JB JS Open Access
Alkhouri S, Michelberger M, Parikh J, Fang CJ, Harris C, Nelson K, Maitra S, Wentz B.   +7 more
europepmc   +1 more source

The ability to pick biotech talent: Being a better interviewer moves ‘you’ up the ladder

, 1969
David G. Jensen
openalex   +2 more sources