Results 31 to 40 of about 6,290,967 (378)
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
Animal, 2015 An understanding of the perceived importance of a variety of factors affecting the ease of handling of sheep and the interactions between these factors is valuable in improving profitability and welfare of the livestock.
C.L. Burnard +3 more
doaj +1 more source
STEM 1, 2, 3: Levelling Up in Primary Schools
Education Sciences, 2022 Recent research advocating the educational value of engaging primary students in authentic integrated STEM inquiry projects also identifies challenges for teachers aspiring to high-quality student-learning experiences.
Jennifer Way +2 more
doaj +1 more source
Andres Quintero Interview [PDF]
, 2014 Andres Taborda ’15 and Jennifer Giffels ’14 of the Model OAS course in the Department of Political Science interviewed Andres Quintero, who is an expert in peace and conflict resolution.
Giffels, Jennifer, Taborda, Andres
core +1 more source
Molecular Oncology, EarlyView.Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma +9 more
wiley +1 more source
Desenvolvimento e Meio Ambiente, 2016 This paper deals with the perception of animal welfare (AW) on the part of rural entrepreneurs, agriculture/cattle raising technicians and poultry farm workers in organic egg production in the state of São Paulo.
Fabiola Fernandes Schwartz +1 more
doaj +1 more source
Frontiers in Education, 2022 To prevent the negative trend regarding youths’ physical activity (PA) level, schools have been promoted as an appropriate arena for facilitating increased PA among youths.
Sondre Arntzen Lomsdal +2 more
doaj +1 more source
The battle for the whistleblower : an interview with John Kiriakou [PDF]
, 2019 Whistleblowing, or speaking truth to power, is complex. How truth telling is shaped is an important issue, as is the legitimacy of the individual who speaks out.
Bushnell, Alexis +2 more
core
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source