Results 31 to 40 of about 2,620,970 (313)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interview: Interview with Gisbert Schneider [PDF]
Future Medicinal Chemistry, 2012 Gisbert Schneider studied biochemistry and computer science at the Free University of Berlin, Germany, where he received his doctoral degree in 1994. After several international post-doctoral research activities he joined F.Hoffmann-La Roche Pharmaceuticals in Basel, Switzerland, where he headed the cheminformatics group until 2001.
openaire +2 more sources
Participants’ home as an interview context when studying sensitive family issues
Journal of Comparative Social Work, 2013 This article considers the meaning of the participants’ home as an interview context when studying sensitive family issues. The article is based on two qualitative family studies by the authors on foster children’s perspectives on their home and their ...
Kati Hämäläinen, Susanna Rautio
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Journal of Pharmaceutical Policy and Practice, 2017 Background The inappropriate use of antimicrobials is a problem worldwide. To target future interventions, a thorough understanding of the reasons behind this current behaviour is needed. Within the EU, the culture of antimicrobial use has been intensely
Susanne Kaae, Admir Malaj, Iris Hoxha
doaj +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Questions and questioning in Montenegrin police interviews [PDF]
, 2010 Questions are never asked without a reason, and whenever a question is made, it becomes a vehicle for another action. Questions, on their most basic level, endeavour to strike up an epistemic balance between the interlocutors in that the questioner ...
Cerovic, Marijana
core
Cronologia vieții literare românești (CVLR). Studiu de caz; Anul 1971 (II) [PDF]
Revista de Istorie și Teorie Literară, 2022 This article is mainly about “Anul 1961” and “Anul 1971” from CVLR – the Communist Era, putting in scene a series of lists about these years, by famous authors of that time (being quoted frequently in that moment), in the newspapers that appeared in 1961
Andrei Milca
doaj