Results 141 to 150 of about 1,511,334 (265)

Development and Validation of Machine Learning‐Based Marker for Early Detection and Prognosis Stratification of Nonalcoholic Fatty Liver Disease

Advanced Science, EarlyView.
This study constructs a stacked multimodal machine learning model for nonalcoholic fattly liver disease (NAFLD) by integrating genetic and clinical features, and synthesize an in‐silico quantitative marker (ISNLD) that enables personalized risk stratification for intrahepatic and extrahepatic outcomes of high‐risk individuals of NAFLD.
Lushan Xiao, Lin Zeng, Jiaren Wang, Chang Hong, Ziyong Zhang, Chengkai Wu, Hao Cui, Yan Li, Ruining Li, Shengxing Liang, Qijie Deng, Wenyuan Li, Xuejing Zou, Pengcheng Ma, Li Liu   +14 more
wiley   +1 more source

What are the Latent Topics Associated with Experience in Flipped Learning? An Empirical Investigation of University Students' Interview Responses

, 2021
Kyung‐Hee Park, Yonghwan Bang
openalex   +2 more sources

Integrative Multi‐Omics and Routine Blood Analysis Using Deep Learning: Cost‐Effective Early Prediction of Chronic Disease Risks

Advanced Science, EarlyView.
Omicsformer, a deep learning model, integrates multi‐omics and routine blood data to accurately predict risks for nine chronic diseases, including cancer and cardiovascular conditions. Validated using large scale clinical data, it reveals early risk trajectories, advancing personalized medicine and offering a cost‐effective, community‐based solution ...
Zhibin Dong, Pei Li, Yi Jiang, Zhihan Wang, Shihui Fu, Hebin Che, Meng Liu, Xiaojing Zhao, Chunlei Liu, Chenghui Zhao, Qin Zhong, Chongyou Rao, Siwei Wang, Suyuan Liu, Dayu Hu, Dongjin Wang, Juntao Gao, Kai Guo, Xinwang Liu, En Zhu, Kunlun He   +20 more
wiley   +1 more source

Students' intrinsic motivation in EFL academic writing: Topic-based interest in focus

Heliyon
Writing as a productive skill is extremely challenging for EFL students. To promote their writing effectiveness, students' intrinsic motivation must be enhanced by allowing them to self-assign writing topics or write about topics of interest.
Ali Abbas Falah Alzubi, Mohd Nazim
doaj  

Mapping Accessibility Assignments into Core Computer Science Topics: An Empirical Study with Interviews and Surveys of Instructors and Students [PDF]

Emily Kuang, Selah Bellscheidt, Di Pham, Kristen Shinohara, Catherine M. Baker, Yasmine N. Elglaly   +5 more
openalex   +1 more source

Examining the Effectiveness of Conducting Informational Interviews toward Contextualizing Topics in Business Education

, 2022
Esmail Mohebbi
openalex   +1 more source

Exploring the Latent Information in Spatial Transcriptomics Data via Multi‐View Graph Convolutional Network Based on Implicit Contrastive Learning

Advanced Science, EarlyView.
STMIGCL is an implicit contrastive learning‐based multi‐view graph convolutional network framework designed for downstream tasks such as spatial domain recognition, trajectory inference, and spatially variable gene identification. By combining multi‐view learning with contrastive learning and employing contrastive learning methods that enhance contrast
Sheng Ren, Xingyu Liao, Farong Liu, Jie Li, Xin Gao, Bin Yu   +5 more
wiley   +1 more source

Neuraminidase 1 Exacerbated Glycolytic Dysregulation and Cardiotoxicity by Destabilizing SIRT1 through Interactions with NRF2 and HIF1α

Advanced Science, EarlyView.
NEU1, a key regulator of glycolysis, is markedly upregulated following DOX treatment. This upregulation is attributed to HIF1α’s transcriptional repression, requiring intricate interactions with NRF2. Increased NEU1 facilitates SIRT1 lysosomal degradation, contributing to aberrant glycolytic phenotype and cardiac damage.
Ting Gao, Yufeng Tang, Tao Zeng, Jie Wang, Xiaohui Zhang, Qingbo Liu, Xun Guan, Xinyu Tang, Guangping Lu, Jiahao Li, Mingrui Liu, Dongmei Zhang, Sixuan Lv, Junlian Gu   +13 more
wiley   +1 more source

Data from questionnaire and interview topic guide

, 2022
Sara Bawa, Claire Bustin, Chathura Munasinghe   +2 more
openalex   +2 more sources

PSMD14 Stabilizes SLC7A11 to Ameliorate Glucocorticoid‐Induced Osteoporosis by Suppressing Osteocyte Ferroptosis

Advanced Science, EarlyView.
Glucocorticoid‐induced osteoporosis (GIOP) triggers osteocyte ferroptosis via SLC7A11 degradation. PSMD14 stabilizes SLC7A11 by counteracting glucocorticoid‐driven ubiquitination, preserving cystine uptake and glutathione synthesis. AAV‐mediated PSMD14 delivery or its agonist Pantethine rescues osteocyte survival and bone loss in GIOP mice.
Yifeng Shi, Qian Tang, Sunren Sheng, Hongyi Jiang, Chen Jin, Chencheng Zhou, Chenglong Xie, Lin Zheng, Di Zhang, Hui Xu, Cong Xu, Haiwei Ma, Guangheng Xiang, Wenfei Ni, Xiaoyun Pan, Lei Yang, Huazi Xu, Yu Qian, Aimin Wu, Xiangyang Wang, Gang Zheng   +20 more
wiley   +1 more source