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. Due to the increase in the population of the elderly, there is a growing trend in some diseases such as cognitive disorders (dementia) which are common in this era, and the diagnosis and treatment of this disease are still facing challenges. Therefore,
Fatemeh Ghonoodi +4 more
doaj +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Relato das percepções surgidas da experiência da recolha dos dados da investigação qualitativa "Representações Sociais da Internação Domiciliar na terminalidade: o olhar do cuidador familiar".
Stefanie Griebeler Oliveira +5 more
doaj
Health topics emerged from brief‐motivational interviewing: A randomized clinical trial [PDF]
Michelle C Arnett +4 more
openalex +1 more source
A trend map is a visual depiction of relevant trends influencing the system around a given topic. Developing a trend map can help a group deepen their understanding of an issue through exploring related history, identifying key external factors, and ...
Hallie Preskill, Marcie Parkhurst
core
This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart +4 more
wiley +1 more source
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman +4 more
wiley +1 more source
Background People with chronic obstructive pulmonary disease (COPD) are frequently admitted to hospital and experience challenges with their medicines.
Torbjørn Nygård +4 more
doaj +1 more source
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
Introduction Refractory or unexplained chronic cough (RUCC) is a common clinical problem with no effective diagnostic tools. The Sensations and Triggers Provoking Cough questionnaire (TOPIC) was developed to characterise cough in RUCC versus cough in ...
Janelle Yorke +11 more
doaj +1 more source

