Results 131 to 140 of about 874,138 (343)

Sirtuin2 suppresses the polarization of regulatory T cells toward T helper 17 cells through repressing the expression of signal transducer and activator of transcription 3 in a mouse colitis model

Immunity, Inflammation and Disease
Introduction Regulatory T cells (Tregs) play an important role in inflammatory bowel diseases (IBDs) through modulating intestinal inflammation. However, the factors affecting Treg function and plasticity during IBD progression are not thoroughly ...
Liuqing Ge, Min Xu, Meifang Huang, Shaoping Liu, Zhidai Zhou, Ziqin Xia, Qiu Zhao, Feng Zhou   +7 more
doaj   +1 more source

Emerging technologies and current challenges in intratumoral microbiota research

Frontiers in Cellular and Infection Microbiology
Intratumoral microbiota are now recognized as an integral component of the tumor microenvironment, affecting tumor initiation, metastatic potential, immune modulation, and treatment response.
Zhiyue Wang, Zhiyue Wang, Tianqi Zhang, Tianqi Zhang, Yang Liu, Yang Liu   +5 more
doaj   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

To explore the postoperative nutritional status and factors influencing prognosis in patients with chronic constipation complicated by malnutrition

Frontiers in Medicine
BackgroundMany patients with constipation also suffer from varying degrees of malnutrition, and the relationship between the two conditions is a vicious cycle.
Le Wang, Le Wang, Hongliang Tian, Hongliang Tian, Hongliang Tian, Long Li, Long Li, Chen Ye, Chen Ye, Jiaqu Cui, Jiaqu Cui, Zhiliang Lin, Zhiliang Lin, Bo Yang, Bo Yang, Di Zhao, Di Zhao, Ning Li, Ning Li, Xiaobo Feng, Qiyi Chen, Qiyi Chen, Qiyi Chen   +22 more
doaj   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Probiotics and Intestinal Diseases [PDF]

Annals of Nutrition and Metabolism, 2010
Philip, Rosenstiel, Eduard F, Stange
openaire   +2 more sources

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

Intestinal Coccidiosis in a Patient with Alpha-chain Disease [PDF]

, 1974
K. Henry, R.G. Bird, W F Doe
openalex   +1 more source

Meta-analysis of the gut microbiome of Parkinson’s disease patients suggests alterations linked to intestinal inflammation [PDF]

, 2020
Stefano Romano, George M. Savva, Janis R. Bedarf, Ian G. Charles, Falk Hildebrand, Arjan Narbad   +5 more
openalex   +1 more source