Results 301 to 310 of about 9,941,870 (340)

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Host‐Guest Inclusion Chemistry From Supramolecular Architecture Enabling Anti‐Biofouling Surfaces for Oesophagus Stents

Advanced Functional Materials, EarlyView.
A slippery coating with exceptional anti‐biofouling performance is developed using biocompatible materials for oesophagus stents. Host‐guest inclusion complex formation capabilities of FDA‐approved supramolecules, cyclodextrins are exploited, which significantly enhances the stability of the surface.
Jianhui Zhang, Haowei Wang, Sourabh Dogra, Xiaoye Zhao, Wenqing Chen, Arpan Gupta, Manish K. Tiwari, Vikramjeet Singh   +7 more
wiley   +1 more source

Single Cell Integration Characterises Metaplasia in Inflammatory Intestinal Diseases

Oliver AJ, Huang N, Li R, Bartolome-Casado R, Nilsen HR, Gudino V, Melon-Ardanaz CdIBe, Fitzpatrick MEB, Provine NM, Polanski K, Koplev S, Milchsack LM, Dann E, Predeus AV, Cakir B, To K, Prete M, Chapman JA, Masi AC, Stephenson E, Engelbert J, Lobentanzer S, Perera S, Richardson L, Kapuge R, Wilbrey-Clark A, Semprich CI, Moy M, Ellams S, Tudor CL, Joseph P, Garrido-Trigo A, Corraliza CdIBe, Oliver TR, Hook CE, Saez-Rodriguez J, James KR, Meyer KB, Mahbubani KT, Saeb-Parsy K, Zilbauer M, Hoivik ML, Baekkevold ES, Salas CdIBe, Stewart CJ, Berrington JE, Klenerman P, Haniffa M, Jahnsen FL, Elmentaite R, Teichmann SA.   +50 more
europepmc   +1 more source

Novel Less Toxic, Lymphoid Tissue‐Targeted Lipid Nanoparticles Containing a Vitamin B5‐Derived Ionizable Lipid for mRNA Vaccine Delivery

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
The top‐performing lipid nanoparticle, incorporating a novel ionizable lipid derived from vitamin B5, demonstrates high mRNA transfection efficiency, low toxicity, favorable stability, targeted delivery to lymphoid tissues, and high immunogenicity, showing promise as a carrier for mRNA vaccines for infectious diseases and cancer.
Soyeon Yoo, Muhammad Faisal, Seo‐Hyeon Bae, Kounghwa Youn, Hyo‐Jung Park, Sung Pil Kwon, Il Kwon Hwang, Jisun Lee, Hyeong Jun Kim, Jae‐Hwan Nam, Gyochang Keum, Eun‐Kyoung Bang   +11 more
wiley   +1 more source

Glepaglutide‐Loaded Foam for the Induction of Mucosal Healing in the Treatment of Inflammatory Bowel Disease

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
Glepaglutide (GL), a GLP‐2 analog with an extended half‐life (50 h), is currently undergoing clinical trials for patients with short bowel syndrome. GL requires subcutaneous injection, which poses challenges for potential patient compliance. To address this challenge, we loaded GL into a rectal foam formulation using CO2 as a permeation enhancer to ...
Wunan Zhang, William Van den Bossche, Hafsa Yagoubi, Espoir K Kambale, Khadija Wahni, Tanya Saxena, Léo Guilbaud, Tom G. Moreels, Joris Messens, Ana Beloqui   +9 more
wiley   +1 more source

Synthetic Bilirubin‐Based Nanomedicine Protects Against Renal Ischemia/Reperfusion Injury Through Antioxidant and Immune‐Modulating Activity

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
BX‐001N, a polyethylene glycol‐conjugated bilirubin 3α nanoparticle, is the first GMP‐grade, synthetic bilirubin‐based nanomedicine. It effectively attenuates acute renal injury, facilitates subacute renal recovery, and suppresses chronic fibrosis after renal ischemia/reperfusion injury via anti‐oxidant and immune‐modulating activity.
Ji‐Jing Yan, Hyunjin Kim, Bomin Kim, Honglin Piao, Joon Young Jang, Tae Kyeom Kang, Wook‐Bin Lee, Dohyeon Kim, Seunghyun Jo, Duckhyang Shin, Sharif MD Abuzar, Myung L. Kim, Jaeseok Yang, Sangyong Jon   +13 more
wiley   +1 more source

A complicated case of perianal mucinous adenocarcinoma complicating necrotizing fasciitis

Asian Journal of Surgery
Xuedong Zhang, Tao Wang, Faxin Li, Mingming Chai   +3 more
doaj  

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Gastrointestinal Microenvironment Responsive Nanoencapsulation of Probiotics and Drugs for Synergistic Therapy of Intestinal Diseases.

ACS Nano, 2023
The gut microbiota are prominent in preserving intestinal environmental homeostasis and managing human health, and their dysbiosis has been directly related to many kinds of intestinal diseases.
Pandi Peng, Tao Feng, Xue Yang, Chaofan Nie, Luofeng Yu, Rui Ding, Qiang Zhou, Xue-bing Jiang, Peng Li   +8 more
semanticscholar   +1 more source

A critical role of AMP‐activated protein kinase in regulating intestinal nutrient absorption, barrier function, and intestinal diseases

Journal of Cellular Physiology, 2022
As one of the most important organs in animals, the intestine is responsible for nutrient absorption and acts as a barrier between the body and the environment. Intestinal physiology and function require the participation of energy.
Zhihui Wu, Chengfei Xu, Teng Zheng, Qihui Li, Siwang Yang, Jiayuan Shao, W. Guan, Shihai Zhang   +7 more
semanticscholar   +1 more source

Cyanidin-3-O-glucoside and its phenolic metabolites ameliorate intestinal diseases via modulating intestinal mucosal immune system: potential mechanisms and therapeutic strategies

Critical reviews in food science and nutrition, 2021
The incidence of the intestinal disease is globally increasing, and the intestinal mucosa immune system is an important defense line. A potential environmental cause to regulate gut health is diet.
Zhen Cheng, X. Si, Hui Tan, Zhihuan Zang, Jinlong Tian, C. Shu, Xiyun Sun, Zhiying Li, Qiao Jiang, Xianjun Meng, Yi Chen, Bin Li, Yuehua Wang   +12 more
semanticscholar   +1 more source