Low‐intervention clinical trials in Spain: Do they progress?
British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1438-1444, May 2026.Abstract Aims Low‐Intervention Clinical Trials (LICTs) are generally pragmatic trials that investigate medicinal products already authorized for use. In 2014, simplified regulatory frameworks were introduced for LICTs with the aim of reducing regulatory burden and operational complexity, to foster non‐commercial clinical trials (NCCTs); the mandatory ...
Claudia Erika Delgado‐Espinoza +4 more
wiley +1 more source
Cancer Medicine, Volume 15, Issue 5, May 2026.ABSTRACT Objective We aimed to evaluate medical decisions regarding urinary tract infection (UTI), describe associated microorganisms, and assess potential risk factors for percutaneous nephrostomy‐related UTI (UTI‐PN). Methods Oncological patients who underwent percutaneous nephrostomy (PN) were included. We assessed percutaneous nephrostomy procedure‐
Jeferson Rodrigo Zanon +3 more
wiley +1 more source
Long-Term Complication: Colovaginal Fistula Nine Years after Laparoscopic Sacrocolpopexy. [PDF]
CRSLSWang S +6 more
europepmc +1 more source
Bowel Ischemia: A Life‐Threatening Complication of an Infected Urachal Cyst in an Adolescent
Clinical Case Reports, Volume 14, Issue 5, May 2026.ABSTRACT While infection is a recognized complication of congenital urachal cysts, progression to an inflammatory phlegmon causing bowel ischemia is an exceptionally rare and life‐threatening event in the pediatric population. We report the case of a 14‐year‐old male with a 7‐year history of an infraumbilical mass who presented with an acute abdomen ...
Sheeraz Ali +7 more
wiley +1 more source
Real-World Efficacy and Safety of Adalimumab Biosimilar (HS016) in Biologic-Naïve Patients with Perianal Fistulizing Crohn's Disease: A Prospective, Single-Arm, Observational Study. [PDF]
Drug Des Devel TherYu Q +9 more
europepmc +1 more source
Hydatid Cyst of the Thyroid Gland With Concurrent Hepatic Involvement: A Rare Case Report
Clinical Case Reports, Volume 14, Issue 5, May 2026.ABSTRACT Hydatidosis, caused by Echinococcus granulosus, most commonly affects the liver and lungs, while thyroid involvement is exceptionally rare and can mimic other cystic thyroid lesions. We report a 40‐year‐old woman with no history of animal exposure who presented with anterior neck swelling, odynophagia, and abdominal discomfort. She had a prior
Hana Saffar, Aysan Nozheh, Maral Edalati
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Magnetic Resonance Enterography Predicts Long-Term Outcomes in Crohn's Disease: A Systematic Review and Meta-Analysis. [PDF]
JGH OpenWu S +6 more
europepmc +1 more source
Engineering Reports, Volume 8, Issue 5, May 2026.The article describes the design and manufacturing process of a novel pediatric high‐fidelity pathological mannequin for clinical training on unanticipated difficult airway management using rigid and flexible bronchoscopy. The mannequin has been developed from the CT scans of a 19‐month‐old polysyndromic patient (Crouzon Syndrome), thanks to the ...
Marta Mencarelli +5 more
wiley +1 more source
Hyperechoic mesenteric fat on preoperative intestinal ultrasound predicts early postoperative recurrence in Crohn's disease. [PDF]
Insights ImagingLiang Z +7 more
europepmc +1 more source
LL‐37: Biological Mechanisms and Emerging Therapeutic Applications in Intestinal Disease
Immunity, Inflammation and Disease, Volume 14, Issue 5, May 2026.ABSTRACT Human cathelicidin peptide LL‐37 is encoded by the CAMP gene and plays a key role in innate immunity. It maintains intestinal homeostasis through antibacterial, immunomodulation, and tissue repair functions. This paper reviews the multiple functions of LL‐37 in the intestinal‐immune axis and its contribution to intestinal immune homeostasis. A
Qichao Liu, Peng Xu, Cheng Zhang
wiley +1 more source