Results 51 to 60 of about 55,211 (293)

Mechanically Active Hydrogel for Healing Intestinal Fistulas through the YAP‐Mediated Mechanosensitization of Intestinal Epithelial Cells

Advanced Science
Intestinal fistula is a serious condition characterized by abnormal connections between the intestine and surrounding tissues. Despite advances in comprehensive management of intestinal fistulas, patients often need to undergo definitive surgery and face
Ze Li, Jiayang Li, Kang Chen, Guiwen Qu, Shuanghong Yang, Sicheng Li, Ye Liu, Yitian Teng, Rui Ma, Jinjian Huang, Peige Wang, Jianan Ren, Xiuwen Wu   +12 more
doaj   +1 more source

A rare complication of Meckel's diverticulum: A fistula between Meckel's diverticulum and the appendix

Asian Journal of Surgery, 2012
Meckel diverticulum is the most common congenital anomaly of the small intestine, occurring in about 2%–4% of the population. Meckel diverticulum results from incomplete closure of the omphalomesenteric duct.
Ping-Fu Yang, Chau-Yun Chen, Fang-Jung Yu, Sheau-Fang Yang, Yi Ting Chen, Li-Chun Kao, Jaw-Yuan Wang   +6 more
doaj   +1 more source

TTNPB Promotes Human Pluripotent Stem Cell‐to‐Neural Stem Cell Transition via Modulation of Chromatin Accessibility and the S‐(5′‐adenosyl)‐L‐homocysteine/Choline Metabolic Network

Advanced Science, EarlyView.
A retinoic acid receptor agonist, TTNPB, drives the efficient generation of advanced neural stem cells (ANSCs) from human pluripotent stem cells. TTNPB‐centered chromatin remodeling and metabolic reprogramming, promote neuroectoderm commitment. The resulting cells show robust neural potential and functional efficacy in a rat depression model.
Ruilin Du, Yudi Ren, Qiaoqiao Meng, Peng Wei, Ruyu Zhu, Junjie Bao, Ye Yang, Shuo Yan, Chaorong Yue, Xueying Zhu, Shuo Cao, Chunxia Hao, Wei Sun, Yongli Song, Xihe Li, Zhimin Wu, Siqin Bao, Yanglin Chen   +17 more
wiley   +1 more source

Comparative effectiveness of ustekinumab versus infliximab in the management of perianal fistulizing Crohn's disease: a retrospective study in China [PDF]

Intestinal Research
Background/Aims Ustekinumab (UST) and infliximab (IFX) are both effective in the treatment of perianal fistulizing Crohn’s disease (CD), but limited research has focused on comparing the efficacy of UST versus IFX in this field.
Mengqi Chen, Zihan Chen, Jianming Lin, Linxin Liu, Tong Tu, Xiaoling Li, Baili Chen, Yao He, Minhu Chen, Zhirong Zeng, Xiaojun Zhuang   +10 more
doaj   +1 more source

Operative strategy for fistula-in-ano without division of the anal sphincter [PDF]

, 2013
We would like to thank Mr ER MacDonald for his contribution in data collection during the early years of the study. The material in this paper was presented as a poster at the annual meeting of the American Society of Colon and Rectal Surgeons held in ...
Abbas MA, AKY Fung, EH Aly, Goldberg SM, GV Card, NP Ross, Rojanasakul A, Sainio P, SR Yule   +8 more
core   +1 more source

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

Tube choledochoureterostomy: A simple method for bile diversion [PDF]

, 1990
A technique of bile diversion by tube choledochoureterostomy has been devised for the purpose of studying the role of bile in the intestinal absorption of drugs. This method was used in six dogs. No technical difficulties or major complications developed,
Andrews W, Barringer M, Ericzon B G, Hiroyuki Furukawa, Kapsinow R, Knoebel L K, Marshall R W, Oscar Imventarza, Pearce R M, Rous P, Satoru Todo, Thomas E. Starzl, You Min Wu   +12 more
core   +1 more source

Phocaeicola coprophilus‐Derived 6‐Methyluracil Attenuates Radiation‐Induced Intestinal Fibrosis by Suppressing the IDO1‐Kynurenine‐AHR Axis

Advanced Science, EarlyView.
IR‐induced dysbiosis depletes P. coprophilus and its metabolite 6‐methyluracil, leading to disinhibition of the IDO1‐Kyn‐AHR axis. This results in sustained fibroblast activation and collagen deposition, driving radiation induced intestinal fibrosis. ABSTRACT Therapeutic options for radiation‐induced intestinal fibrosis (RIF) remain limited. This study
Jiaxin Zhang, Zhen Wang, Shuang Li, Chao Luo, Han Li, Shengjie Ma, Pai Wang, Heshi Liu, Lijun Sun, Yue Yin, Weizhen Zhang, Quan Wang   +11 more
wiley   +1 more source

Successful treatment of enterocutaneous fistula in a premature newborn by using octreotide

The Turkish Journal of Pediatrics, 2004
A premature newborn with an enterocutaneous fistula after repair of duodenal perforation is reported to emphasize the therapeutic effect of octreotide in persistent fistula even in a very small infant.
Ilker Büyükyavuz, Ibrahim Karnak, Sule Yiğit, F Cahit Tanyel   +3 more
doaj   +1 more source

Oral Celastrol Nanomedicine Targeting Intestinal Antigen‐Presenting Cells to Effectively Mitigate Autoimmune Uveitis via Gut‐Retina Axis

Advanced Science, EarlyView.
Oral nanoCEL exhibits effective intestinal targeting of antigen‐presenting cells and restores the Th17/Treg balance in lymph nodes and spleen, ultimately protecting the blood‐retinal barrier by inhibiting peripheral immune cell infiltration and suppressing retinal glial cell activation.
Jinrun Chen, Yuqin Wu, Bofei Xu, Jiabei Hou, Yijing Li, Yuhan Hu, Yutuo Zhu, Wenqiao Zhang, Shuqi Feng, Huanting Jin, Yuchen Cheng, Yuanyuan Jin, Jianhong Zhou, Xingyi Li   +13 more
wiley   +1 more source