Results 61 to 70 of about 800,833 (311)

In Situ Programming of the Tumor Microenvironment to Alleviate Immunosuppression for Pancreatic Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
cmExoaCD11b induced the repolarization of immunosuppressive M2 macrophages into pro‐inflammatory M1 phenotype, thereby promoting the proliferation and activation of CD8+ T cells and reversing the immunosuppressive state of the tumor microenvironment.
Man Sun   +14 more
wiley   +1 more source

Targeting Neutrophil/Eosinophil Extracellular Traps by Aptamer‐Functionalized Nanosheets to Overcome Recalcitrant Inflammatory Disorders

open access: yesAdvanced Science, EarlyView.
In this study, C‐TAH, as multifunctional nanosheets, is developed with tannic acid and histone aptamer coverage. C‐TAH displays mild cytotoxicity, robust dsDNA and NETs/EETs binding efficiency, and potent antioxidant and antibacterial ability in vitro. C‐TAH treatment ameliorates dysregulated inflammation and restores hearing function in animal models,
Yongqiang Xiao   +13 more
wiley   +1 more source

An unusual case of hematemesis: Spontaneous reno-duodenal fistula

open access: yesJournal of Digestive Endoscopy, 2014
Different diseases may cause gastrointestinal bleeding. A fistula infrequently manifest with severe intestinal bleeding, when excluding those directly involving vascular structures.
Vincenzo De Francesco   +3 more
doaj   +1 more source

A Novel Cranial Bone Transport Technique Repairs Skull Defect and Minimizes Brain Injury Outcome in Traumatic Brain Injury Rats

open access: yesAdvanced Science, EarlyView.
This study introduces a novel, safe, and effective surgical technique: Cranial bone transport (CBT) to improve traumatic brain injury (TBI) outcomes in rats. CBT significantly accelerated skull defect bone repair in addition to its promoting effects on neurological function recovery. This work provides an alternative therapy for patients suffering from
Shanshan Bai   +20 more
wiley   +1 more source

Engineering DNA Origami Captors for TGFβ1 Sequestration to Enhance Tumor Immune Modulation and Therapy

open access: yesAdvanced Science, EarlyView.
Programmable DNA framework captors effectively deplete circulatingtransforming growth factor‐β1 (TGFβ1) through fast systemic clearance and reshape the tumor immune microenvironment, alleviating immunosuppression to inhibit tumor progression. Abstract Efficient modulation of pivotal immune‐regulatory molecules to leverage the tumor microenvironment ...
Xiao Chen   +7 more
wiley   +1 more source

Atrial Fibroblasts‐Derived Extracellular Vesicles Exacerbate Atrial Arrhythmogenesis

open access: yesAdvanced Science, EarlyView.
Exosome miR‐224‐5p derived from angiotensin II‐treated atrial fibroblasts creates a substrate for AF by promoting atrial electrical remodeling. Increased exosome miR‐224‐5p enhances AF susceptibility by inhibiting CACNA1c expression and decreasing ICa current of atrial cardiomyocytes.
Yue Yuan   +13 more
wiley   +1 more source

Reoperative pouch surgery for suspected Crohn's‐related complications aided by biologic coverage: Early experience from an inflammatory bowel disease center

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
This paper demonstrates that revisional/redo ileal pouch anal anastomosis (IPAA) surgery with concurrent biologic therapy provides a viable, stoma‐free alternative for patients with Crohn's disease‐like complications, showing a high functioning pouch rate and expanding options for managing pouch failure.
Mehmet Gulmez   +8 more
wiley   +1 more source

Gallstone ileus: An unusual cause of intestinal obstruction

open access: yesRadiology Case Reports, 2022
Gallstone ileus is an infrequent cause of intestinal obstruction. It is typically the result of cholecystoduodenal fistula, computed tomography scan is the best modality for the diagnosis.
Mohamed Bouziane   +5 more
doaj  

Analysis of hospital costs for robotic and open pancreatectomy incurred during the implementation of a robotic pancreatectomy program at a cancer center

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
In this matched cohort study, total costs associated with robotic pancreatectomy were significantly lower than those associated with open pancreatectomy. High intraoperative costs associated with robotic pancreatectomies can be mitigated by other hospital related factors such as length of stay, number of medication prescriptions, and standardization of
Heather G. Lyu   +9 more
wiley   +1 more source

OBSERVATIONS ON DIGESTION IN THE PIG USING A RE-ENTRANT INTESTINAL FISTULA

open access: yes, 1963
Sixty-four 12- to 24-hour collections were made of digesta flowing from re-entrant ileal fistulas of two pigs used to study the digestibility and rate of passage of various materials in the proximal digestive tract.
H. M. Cunningham   +2 more
semanticscholar   +1 more source

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